Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside
Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside
复制标题
转运和磷酸化作为阿糖胞苷抗肿瘤作用的因素
作者：
D. Kessel;T. Hall;I. Wodinsky
携带不同可移植性白血病的小鼠的存活率与阿糖胞苷治疗进行了比较，并在体外进行了药物的摄取和随后的磷酸化。核苷酸形成能力与反应相关，显然是药物敏感性的重要决定因素。药物摄取，虽然显然是介导的，是相似的，在所有的细胞系。
Survival of mice bearing different transplantable leukemias and treated with cytosine arabinoside was compared with uptake and subsequent phosphorylation of the drug in vitro. Capacity for nucleotide formation was correlated with response and is apparently an important determinant of drug sensitivity. Drug uptake, although apparently mediated, was similar in all cell lines.