Mathematical models of immune effector responses to viral infections: Virus control versus the development of pathology
Mathematical models of immune effector responses to viral infections: Virus control versus the development of pathology
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DOI：
10.1016/j.cam.2004.08.016
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发表时间：
2005-12-01
影响因子：
2.4
通讯作者：
Wodarz, D
中科院分区：
文献类型：
--
作者：
Wodarz, D
本文综述了研究裂解和非裂解免疫反应对控制病毒感染的重要性的数学模型。裂解免疫反应通过杀死受感染的细胞来对抗病毒，而非裂解免疫反应通过抑制病毒复制而使受感染的细胞存活来对抗病毒。这些模型提出了解决感染所需的免疫反应的类型或组合，这些感染的特征不同，如病毒复制速度和病毒诱导的靶细胞死亡率。这一框架随后被应用于持续性感染和病毒进化。研究了随着时间的推移，病毒进化和抗原逃逸如何影响溶血和非溶血反应的相对平衡，以及这可能与从无症状感染向病理的转变有关。这是在丙型肝炎病毒感染的特定背景下讨论的。(C)2005 Elsevier B.V.保留所有权利。
This article reviews mathematical models which have investigated the importance of lytic and non-lytic immune responses for the control of viral infections. Lytic immune responses fight the virus by killing infected cells, while non-lytic immune responses fight the virus by inhibiting viral replication while leaving the infected cell alive. The models suggest which types or combinations of immune responses are required to resolve infections which vary in their characteristics, such as the rate of viral replication and the rate of virus-induced target cell death. This framework is then applied to persistent infections and viral evolution. It is investigated how viral evolution and antigenic escape can influence the relative balance of lytic and non-lytic responses over time, and how this might correlate with the transition from an asymptomatic infection to pathology. This is discussed in the specific context of hepatitis C virus infection. (c) 2005 Elsevier B.V. All rights reserved.