Procalcitonin as a Biomarker in Respiratory Tract Infection
Procalcitonin as a Biomarker in Respiratory Tract Infection
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DOI：
10.1093/cid/cir050
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发表时间：
2011-05-01
影响因子：
11.8
通讯作者：
Gilbert, David N.
中科院分区：
文献类型：
--
作者：
Gilbert, David N.
侵袭性细菌性疾病患者血清降钙素原（PCT）水平迅速升高。PCT水平比C反应蛋白水平增加得更快。此外，PCT水平的快速下降支持细菌感染源对临床管理有反应的证据。在社区获得性细菌性肺炎患者中，连续的PCT水平可作为缩短抗菌治疗疗程的指南。使用新兴的多重实时聚合酶链反应平台检测病毒和细菌呼吸道病原体，应该可以严格评估血清PCT水平升高是否是侵袭性细菌感染的有效生物标志物。
Serum procalcitonin (PCT) levels rapidly increase in patients with invasive bacterial disease. PCT levels increase faster than do C-reactive protein levels. Furthermore, a rapid decrease in the PCT level is supporting evidence that the source of the bacterial infection is responding to clinical management. In patients with community-acquired bacterial pneumonia, sequential PCT levels are useful as a guide to shorter courses of antimicrobial therapy. With use of emerging multiplex real-time polymerase chain reaction platforms for the detection of viral and bacterial respiratory pathogens, it should be possible to critically assess whether an elevated serum PCT level is a valid biomarker of invasive bacterial infection.