Evolutionary history of the closely related group 2 coronaviruses: Porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43
Evolutionary history of the closely related group 2 coronaviruses: Porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43
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DOI：
10.1128/jvi.02675-05
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发表时间：
2006-07-01
影响因子：
5.4
通讯作者：
Van Ranst, Marc
中科院分区：
文献类型：
--
作者：
Vijgen, Leen;Keyaerts, Els;Van Ranst, Marc
人类冠状病毒OC43 （HCoV-OC43）、牛冠状病毒（BCoV）和猪血凝性脑脊髓炎病毒（PHEV）之间的密切遗传和抗原相关性表明，这三种不同宿主特异性的病毒在最近才出现分化。在这项研究中，我们确定了PHEV （PHEV- vw572株）的完整基因组序列，与其他2组冠状病毒相比，PHEV中存在截断的2组特异性ns2基因。利用宽松的分子钟方法，我们实时重建了PHEV、BCoV和HCoV-OC43之间的进化关系，这表明这些物种特异性冠状病毒的共同祖先相对较近。
The close genetic and antigenic relatedness among the group 2 coronaviruses human coronavirus OC43 (HCoV-OC43), bovine coronavirus (BCoV), and porcine hemagglutinating encephalomyelitis virus (PHEV) suggests that these three viruses with different host specificities diverged fairly recently. In this study, we determined the complete genomic sequence of PHEV (strain PHEV-VW572), revealing the presence of a truncated group 2-specific ns2 gene in PHEV in comparison to other group 2 coronaviruses. Using a relaxed molecular clock approach, we reconstructed the evolutionary relationships between PHEV, BCoV, and HCoV-OC43 in real-time units, which indicated relatively recent common ancestors for these species-specific coronaviruses.