MUSCLE STRENGTH AND FATIGUE IN PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS
MUSCLE STRENGTH AND FATIGUE IN PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS
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DOI：
10.1002/mus.21493
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发表时间：
2010-03-01
期刊：
影响因子：
3.4
通讯作者：
Doherty, Timothy J.
中科院分区：
文献类型：
--
作者：
Symonette, Caitlin J.;Watson, Bradley V.;Doherty, Timothy J.
重症肌无力（MG）的特点是疲劳和波动性肌肉无力，导致受损的神经肌肉传递（NMT）。本研究的目的是通过直接测量肌肉力量来量化MG患者的力量和疲劳。肩胛外展肌最大自愿等距收缩方案与常规疲劳和疾病严重程度仪器一起使用。将（D-MG）和非（ND-MG）患者脊髓副神经和腋窝神经重复性神经刺激（RNS）减少的结果与健康对照进行比较。MG患者报告的疲劳程度高于对照组。肌肉力量以D-MG组最低，其次为ND-MG组和对照组。正常肩关节外展疲劳和恢复值在D-MG组和ND-MG组或对照组之间没有差异。RNS下降似乎与疾病严重程度和肌肉无力最相关，但与该人群的疲劳客观测量无关。中国生物医学工程学报，2010
Myasthenia gravis (MG) is characterized by fatigue and fluctuating muscle weakness resulting from impaired neuromuscular transmission (NMT). The objective of this study was to quantify, by direct measurement of muscle force, the strength and fatigue of patients with MG. A maximal voluntary isometric contraction protocol of shoulder abductors was used in conjunction with conventional fatigue and disease-severity instruments. Results from patients with (D-MG) and without (ND-MG) decrement on repetitive nerve stimulation (RNS) of the spinal accessory and axillary nerves were compared with healthy controls. Patients with MG reported greater fatigue than controls. Muscle strength was lowest in the D-MG group, followed by the ND-MG group and controls. Normalized shoulder abduction fatigue and recovery values did not differ between the D-MG and ND-MG groups or controls. The RNS decrement appears to relate best to disease severity and muscle weakness but not to objective measures of fatigue in this population. Muscle Nerve 41: 362-369, 2010