Piezo1 in skin wound healing and related diseases: Mechanotransduction and therapeutic implications
Piezo1 in skin wound healing and related diseases: Mechanotransduction and therapeutic implications
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DOI：
10.1016/j.intimp.2023.110779
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发表时间：
2023-08-13
影响因子：
5.6
通讯作者：
Nie，Xuqiang
中科院分区：
文献类型：
--
作者：
Zhu，Huan;He，Wenjie;Nie，Xuqiang
皮肤伤口愈合是涉及炎症、组织增殖和瘢痕形成的多方面且复杂的过程，所有这些都伴随着机械力的持续施加。机械转导是皮肤接收来自内部和外部环境的物理信号并对其作出反应的机制，将它们转化为细胞内的生化信号。这个复杂的过程依赖于称为机械转换器的专门蛋白质，Piezo1是一个关键的机械敏感离子通道，在这个过程中起着核心作用。本文综述了Piezo1的结构特征，并总结了其在皮肤创伤不同阶段对相应细胞或组织的影响，包括其如何调节皮肤感觉和皮肤相关疾病。旨在揭示Piezo 1在皮肤创伤及皮肤相关疾病中的潜在诊断和治疗价值。Piezo1已被报道是各种器官和组织中机械感觉和转导的重要介质。鉴于其在皮肤中的高表达，Piezo1作为一种重要的细胞膜离子通道，在激活细胞内信号级联中至关重要，这些信号级联触发几种细胞生理功能，包括细胞迁移和肌肉收缩。这些功能有助于调节和改善伤口愈合。
Skin wound healing is a multifaceted and intricate process involving inflammation, tissue proliferation, and scar formation, all of which are accompanied by the continuous application of mechanical forces. Mechanotransduction is the mechanism by which the skin receives and reacts to physical signals from the internal and external environment, converting them into intracellular biochemical signals. This intricate process relies on specialized proteins known as mechanotransducers, with Piezo1 being a critical mechanosensitive ion channel that plays a central role in this process. This article provides an overview of the structural characteristics of Piezo1 and summarizes its effects on corresponding cells or tissues at different stages of skin trauma, including how it regulates skin sensation and skin-related diseases. The aim is to reveal the potential diagnostic and therapeutic value of Piezo1 in skin trauma and skin-related diseases. Piezo1 has been reported to be a vital mediator of mechanosensation and transduction in various organs and tissues. Given its high expression in the skin, Piezo1, as a significant cell membrane ion channel, is essential in activating intracellular signaling cascades that trigger several cellular physiological functions, including cell migration and muscle contraction. These functions contribute to the regulation and improvement of wound healing.