Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish
Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish
复制标题
DOI：
10.1016/s0014-4886(03)00211-5
复制
发表时间：
2003-10-01
影响因子：
5.3
通讯作者：
Dunlop, SA
中科院分区：
文献类型：
--
作者：
King, CE;Wallace, A;Dunlop, SA
Eph酪氨酸激酶受体及其配体ephrin在发育过程中视网膜顶盖地形图的建立中起关键作用。金鱼中ephrin-A2的顶盖上调，与视网膜顶盖图的重建一致，表明在视神经再生期间具有类似的作用（Rodger等人，2000年）。在这里，我们报告了EphA 3，EphA 5和ephrin-A2在视网膜中表达的补充研究。EphA 3和EphA 5随着鼻颞梯度的上升而瞬时上调，而肝配蛋白-A2保持一致。表达谱与发育中的鸡和小鼠不同，表明视网膜Eph受体和配体的不同组合可以产生地形引导信息。(C)2003 Elsevier Science（美国）。All rights reserved.
Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration (Rodger et al., 2000). Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information. (C) 2003 Elsevier Science (USA). All rights reserved.