Circadian phase resetting by a single short-duration light exposure
Circadian phase resetting by a single short-duration light exposure
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DOI：
10.1172/jci.insight.89494
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发表时间：
2017-04-06
期刊：
影响因子：
8
通讯作者：
Klerman, Elizabeth B.
中科院分区：
文献类型：
--
作者：
Rahman, Shadab A.;Hilaire, Melissa A. St.;Klerman, Elizabeth B.
背景在人类中，12分钟的单次曝光和数毫秒的曝光可以改变昼夜节律起搏器的相位。我们研究了人类昼夜节律起搏器的反应，以一个单一的15秒或2分钟的光脉冲管理在生物夜间。26名健康个体参加了为期9天的住院治疗方案，该方案包括评估暴露于单个15秒（n = 8）或2分钟（n = 12）脉冲的强光（9，500勒克斯; 4，100 K荧光）或对照背景昏暗光（< 3勒克斯; n = 6）之前和之后的昏暗光褪黑激素起效时间（DLMO时间）。相移被计算为两个相位估计之间的时钟时间差。15秒和2分钟暴露均诱导的相位延迟位移[中位数（+/- SD）]分别为-34.8 +/- 47.2分钟和-45.4 +/- 28.4分钟，显著高于对照组。（P = 0.04）大于对照条件（提前换档：+ 22.3 +/- 51.3分钟），但彼此无显著差异。与相同条件下收集的历史数据的比较证实了暴露持续时间和相移幅度之间的非线性关系。我们的研究结果强调了人类起搏器对即使是短时间单次暴露于光的敏感性。这些发现可能对夜间暴露于短暂的光刺激引起的昼夜节律紊乱具有现实意义。
BACKGROUND. In humans, a single light exposure of 12 minutes and multiple-millisecond light exposures can shift the phase of the circadian pacemaker. We investigated the response of the human circadian pacemaker to a single 15-second or 2-minute light pulse administered during the biological night.METHODS. Twenty-six healthy individuals participated in a 9-day inpatient protocol that included assessment of dim light melatonin onset time (DLMO time) before and after exposure to a single 15-second (n = 8) or 2-minute (n = 12) pulse of bright light (9,500 lux; 4,100 K fluorescent) or control background dim light (< 3 lux; n = 6). Phase shifts were calculated as the difference in clock time between the two phase estimates.RESULTS. Both 15-second and 2-minute exposures induced phase delay shifts [ median (+/- SD)] of -34.8 +/- 47.2 minutes and -45.4 +/- 28.4 minutes, respectively, that were significantly (P = 0.04) greater than the control condition (advance shift: + 22.3 +/- 51.3 minutes) but were not significantly different from each other. Comparisons with historic data collected under the same conditions confirmed a nonlinear relationship between exposure duration and the magnitude of phase shift.CONCLUSIONS. Our results underscore the exquisite sensitivity of the human pacemaker to even short-duration single exposures to light. These findings may have real-world implications for circadian disruption induced by exposure to brief light stimuli at night.