Mechanisms of Disease: immunopathogenesis of celiac disease
Mechanisms of Disease: immunopathogenesis of celiac disease
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DOI：
10.1038/ncpgasthep0582
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发表时间：
2006-09-01
期刊：
影响因子：
--
通讯作者：
Sollid, Ludvig M.
中科院分区：
文献类型：
--
作者：
Jabri, Bana;Sollid, Ludvig M.
乳糜泻是一种遗传性炎症性疾病，具有自身免疫成分，由摄入膳食面筋引起。难治性直肠和肠病相关T细胞淋巴瘤是该病罕见但独特的并发症。尽管对面筋的适应性免疫反应的重要性已经得到了很好的证实，但现在的观察也表明，面筋诱导的先天应激反应在乳糜泻及其恶性并发症的发病机制中起着核心作用。
Celiac disease is a genetic inflammatory disorder with autoimmune components that is induced by the ingestion of dietary gluten. Refractory sprue and enteropathy-associated T-cell lymphoma are rare but distinctive complications of the disease. Although the importance of the adaptive immune response to gluten has been well established, observations now also point towards a central role for the gluten-induced innate stress response in the pathogenesis of celiac disease and its malignant complications.