Incorporation of gallium-68 into the crystal structure of Prussian blue to form K(68)GaxFe1-x[Fe(CN)6] nanoparticles: toward a novel bimodal PET/MRI imaging agent.
Incorporation of gallium-68 into the crystal structure of Prussian blue to form K(68)GaxFe1-x[Fe(CN)6] nanoparticles: toward a novel bimodal PET/MRI imaging agent.
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DOI：
10.1039/c6dt00962j
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发表时间：
2016-05-31
期刊：
影响因子：
--
通讯作者：
Huang SD
中科院分区：
文献类型：
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作者：
Kandanapitiye MS;Gott MD;Sharits A;Jurisson SS;Woodward PM;Huang SD
由于Ga3+离子与Fe3+离子的相似性，使得在普鲁士蓝（PB）中Fe（III）的晶体位置上，Fe3+离子被Ga3+离子部分取代，形成不同的固溶体KGaxFe1-x[Fe(CN)6] （0<x<1）。这种固溶体具有非常高的热力学稳定性，正如母体PB结构所期望的那样。因此，开发了一种简单的一步式68ga标记方法，用于制备基于PB结构平台的单相纳米颗粒双峰PET/MRI显像剂。与基于金属络合的典型68ga标记反应不同，这种新型无螯合剂的68ga标记反应在酸性条件下具有较快的动力学速度。Ga3+离子不水解，并提供了68ga标记的PB纳米粒子，易于纯化，并且在水溶液中具有极高的抗放射性核素浸出稳定性。
Similarity between the Ga3+ ion and the Fe3+ ion allows for partial replacement of Fe3+ ions with Ga3+ ions in the Fe(III) crystallographic positions in Prussian blue (PB) to form various solid solutions KGaxFe1-x[Fe(CN)6] (0<x<1). Such solid solutions possess very high thermodynamic stability as expected from the parent PB structure. Consequently, a simple one-step 68Ga-labeling method was developed for preparing a single-phase nanoparticulate bimodal PET/MRI imaging agent based on the PB structural platform. Unlike the typical 68Ga-labelling reaction based on metal complexation, this novel chelator-free 68Ga-labeling reaction was shown to be kinetically fast under the acidic conditions. The Ga3+ ion does not hydrolyze, and affords the 68Ga-labelled PB nanoparticles, which are easy to purify and have extremely high stability against radionuclidic leaching in aqueous solution.