Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons.
Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Spectroscopy in Medically-Underserved HIV-Infected Persons.
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DOI：
10.1016/j.jacl.2009.10.005
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发表时间：
2009-12-01
影响因子：
4.4
通讯作者：
Adeyemi, Oluwatoyin
中科院分区：
文献类型：
--
作者：
Swanson, Barbara;Sha, Beverly E.;Keithley, Joyce K.;Fogg, Louis;Nerad, Judith;Novak, Richard M.;Adeyemi, Oluwatoyin
关键词：
HIV感染与血脂异常和心血管事件风险增加有关。很少有研究描述了医疗服务不足，艾滋病毒感染的少数民族，一个群体的特点是健康的差距脂质状态。其目的是使用标准脂质板和核磁共振（NMR）衍生的脂蛋白颗粒谱来表征医疗服务不足，主要是少数民族样本的HIV感染者的脂质谱。参与者是从一项饮食补充剂管理HIV相关血脂异常的随机对照试验中招募的（N=132）。在初始筛选访视时，收集社会人口统计学、临床和行为数据，获得空腹外周静脉血标本，并使用标准脂质组和NMR衍生的脂蛋白颗粒谱分析脂质状态。使用NMR衍生的LDL颗粒截止值，参与者超出目标范围的百分比（50%）高于使用标准LDL胆固醇NCEP截止值（24%）。抗逆转录病毒治疗，特别是蛋白酶的方案，与更高的LDL颗粒浓度。基于NMR衍生的脂蛋白值，大量医疗服务不足、无症状HIV感染的少数民族可能患CHD的风险增加。
HIV infection is associated with dyslipidemia and increased risk for cardiovascular events. Few studies have described lipid status in medically-underserved, HIV-infected ethnic minorities, a group that is characterized by health disparities. The objective was to characterize the lipid profile of a medically-underserved, largely ethnic minority sample of HIV-infected persons using standard lipid panels and nuclear magnetic resonance (NMR) -derived lipoprotein particle profiles. Participants were recruited from a randomized controlled trial of a dietary supplement to manage HIV-related dyslipidemia (N=132). At the initial screening visit, sociodemographic, clinical, and behavioral data were collected, and fasting peripheral venous blood specimens were obtained and lipid status was analyzed using the standard lipid panel and the NMR-derived lipoprotein particle profile. Using NMR-derived LDL particle cutoffs, a higher percentage of participants was outside the target range (50%) than when standard LDL cholesterol NCEP cutoffs were used (24%). Antiretroviral therapy, especially protease inhibitor-containing regimens, was associated with higher LDL particle concentration. Substantial numbers of medically-underserved, asymptomatic HIV-infected minorities may be at increased risk for CHD based on NMR-derived lipoprotein values.
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