Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women
Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women
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DOI：
10.1161/01.hyp.0000165678.63373.8c
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发表时间：
2005-06-01
期刊：
影响因子：
8.3
通讯作者：
Seals, DR
中科院分区：
文献类型：
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作者：
Moreau, KL;Gavin, KM;Seals, DR
随着年龄的增长/绝经，心胸区大弹性动脉的顺应性降低，并在绝经后妇女心血管疾病患病率增加中起重要作用。我们确定氧化应激是否导致绝经后妇女大弹性动脉顺应性降低。在绝经前（n = 10; 23 +/- 1；平均+/- SE）和绝经后雌激素缺乏（n = 21； 55 +/- 1年）的健康久坐女性中，通过急性静脉输注生理盐水（基线对照）和超生理剂量的抗坏血酸来测量颈动脉顺应性。与绝经前妇女相比，绝经后妇女颈动脉依从性在基线对照期间降低56% （P < 0.0001）。抗坏血酸输注使绝经后妇女颈动脉顺应性增加26%(1.11 +/- 0.07至1.38 +/- 0.08 mm(2)/ mmhg × 10(-1)；P < 0.001)，但对绝经前妇女没有影响(2.50 +/- 0.25 vs 2.43 +/- 0.20 mm（2)/ mmhg × 10(-1)）。颈动脉直径、血压和心率均不受抗坏血酸的影响。在合并人群中，动脉抗坏血酸依从性的变化与基线腰臀比（r = 0.56; P = 0.001）、血浆去甲肾上腺素（r = 0.58; P = 0.001）和低密度脂蛋白胆固醇（r = 0.54; P = 0.001）相关。这些结果表明，氧化应激可能是导致久坐、雌激素缺乏的绝经后妇女大弹性动脉顺应性降低的重要机制。增加腹部脂肪储存，交感神经系统活动和低密度脂蛋白胆固醇可能参与氧化应激相关的动脉顺应性抑制绝经后妇女的机制。
The compliance of large elastic arteries in the cardiothoracic region decreases with advancing age/menopause and plays an important role in the increased prevalence of cardiovascular diseases in postmenopausal women. We determined whether oxidative stress contributes to the reduced large elastic artery compliance of postmenopausal women. Carotid artery compliance was measured during acute intravenous infusions of saline ( baseline control) and supraphysiological doses of the potent antioxidant ascorbic acid in premenopausal ( n = 10; 23 +/- 1; mean +/- SE) and estrogen-deficient postmenopausal ( n = 21; 55 +/- 1 years) healthy sedentary women. Carotid artery compliance was 56% lower in postmenopausal compared with premenopausal women during baseline control ( P < 0.0001). Ascorbic acid infusion increased carotid artery compliance by 26% in postmenopausal women ( 1.11 +/- 0.07 to 1.38 +/- 0.08 mm(2)/mm Hg x 10(-1); P < 0.001) but had no effect in premenopausal women (2.50 +/- 0.25 versus 2.43 +/- 0.20 mm(2)/mm Hg x 10(-1)). Carotid artery diameter, blood pressure, and heart rate were unaffected by ascorbic acid. In the pooled population, the change in arterial compliance with ascorbic acid correlated with baseline waist-to-hip ratio ( r = 0.56; P = 0.001), plasma norepinephrine ( r = 0.58; P = 0.001), and LDL cholesterol ( r = 0.54; P = 0.001). These results suggest that oxidative stress may be an important mechanism contributing to the reduced large elastic artery compliance of sedentary, estrogen-deficient postmenopausal women. Increased abdominal fat storage, sympathetic nervous system activity, and LDL cholesterol may be mechanistically involved in oxidative stress - associated suppression of arterial compliance in postmenopausal women.