Plasma catecholamines and their effect on blood lactate and muscle lactate output.
Plasma catecholamines and their effect on blood lactate and muscle lactate output.
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血浆儿茶酚胺及其对血乳酸和肌肉乳酸输出的影响。
DOI：
10.1152/jappl.1984.57.2.321
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Andrew,GM
中科院分区：
文献类型：
--
作者：
Stainsby,WN;Sumners,C;Andrew,GM
本研究旨在检验肾上腺素 (E) 和去甲肾上腺素 (NE) 增加收缩期间原位腓肠肌-跖肌群的净肌肉乳酸输出 (L) 的假设。在肌肉手术分离之前和之后以及在 60 分钟实验期间每隔 10 分钟测量血浆 [E] 和 [NE]。以 1.5 微克 X kg 体重 wt-1 X min-1 的速度静脉输注 E (n = 3) 或 NE (n = 3)，血浆 [E] 和 [NE] 增加三倍。还获得了动脉和肌肉静脉血样本的氧气和乳酸浓度。输注于第 11 分钟开始，重复等长收缩（4 tw/s）于第 31 分钟开始。术前血浆 [E] 和 [NE] 平均分别为 0.34 和 0.52 ng/ml，术后 10 分钟升至 1.12 和 1.19 ng/ml。动脉和静脉乳酸浓度（CaL 和 CvL）在 E 输注期间持续增加，但在 NE 输注期间保持恒定。与早期未输注的相同研究相比，收缩前 10 分钟的最大 L 显着增加。输注不会改变氧气的吸收。结论是，E 会导致 CaL 升高，并且 E 和 NE 都会增加收缩期间的最大净乳酸输出。
This study was designed to test the hypothesis that epinephrine (E) and norepinephrine (NE) increase net muscle lactate output (L) of in situ gastrocnemius-plantaris muscle group during contractions. Plasma [E] and [NE] were measured before and after the surgical isolation of the muscle and at 10-min intervals during the 60-min experiments. Plasma [E] and [NE] were increased threefold by intravenous infusions of E (n = 3) or NE (n = 3) at a rate of 1.5 micrograms X kg body wt-1 X min-1. Arterial and muscle venous blood samples for O2 and lactate concentrations were also obtained. The infusions began at min 11 and repetitive isometric contractions (4 tw/s) began at min 31. The presurgery plasma [E] and [NE] averaged 0.34 and 0.52 ng/ml, respectively, and rose to 1.12 and 1.19 ng/ml 10 min after surgery. Arterial and venous lactate concentrations (CaL and CvL) increased continuously during E infusion but remained constant during NE infusion. Maximal L during the first 10 min of contractions was significantly increased compared with an identical earlier study without infusions. O2 uptake was not changed by the infusions. It is concluded that E causes CaL to rise and that both E and NE increase maximal net lactate output during contractions.