Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities
Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities
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DOI：
10.1037/0894-4105.11.4.535
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发表时间：
1997-10-01
期刊：
影响因子：
2.4
通讯作者：
Lobeck, L
中科院分区：
文献类型：
--
作者：
Arnett, PA;Rao, SM;Lobeck, L
先前的研究一直表明，多发性硬化症（MS）患者的概念推理和设置转换能力受损。其他行政职能则较少受到审查。我们比较了44名多发性硬化症患者和48名人口统计学匹配的对照组的时间排序和语义编码任务以及计划测试（河内塔）。与对照组相比，MS患者经历了语义编码和规划不足，但未受损的时间顺序记忆。对于这两项任务，事后分析表明，慢性进展型MS患者对组间差异的贡献最大。不良的计划和缓慢的信息处理速度的组合被假设为导致MS患者的河内塔表现受损。需要进一步的研究，以探讨MS和社会和职业残疾的语义编码和规划赤字之间的可能关系。
Previous studies have consistently demonstrated impairments in conceptual reasoning and set-shifting abilities in patients with multiple sclerosis (MS). Other executive functions have been less frequently examined. We compared 44 MS patients and 48 demographically matched controls on a temporal-ordering and semantic-encoding task and on a test of planning (Tower of Hanoi). Compared with controls, MS patients experienced deficient semantic encoding and planning but unimpaired temporal-order memory. For both tasks, post hoc analyses indicated that chronic-progressive MS patients contributed most to the group differences. A combination of poor planning and slowed information-processing speed was hypothesized to have contributed to MS patients' impaired Tower of Hanoi performance. Further research is needed to explore the possible relationship between semantic-encoding and planning deficits in MS and social and occupational disabilities.