THE AMPLITUDE AND PERIODICITY OF SYNCHRONIZED RENAL SYMPATHETIC-NERVE DISCHARGES IN ANESTHETIZED CATS - DIFFERENTIAL EFFECT OF BARORECEPTOR ACTIVITY
THE AMPLITUDE AND PERIODICITY OF SYNCHRONIZED RENAL SYMPATHETIC-NERVE DISCHARGES IN ANESTHETIZED CATS - DIFFERENTIAL EFFECT OF BARORECEPTOR ACTIVITY
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DOI：
10.1016/0165-1838(92)90200-z
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发表时间：
1992-10-01
期刊：
影响因子：
--
通讯作者：
NINOMIYA, I
中科院分区：
文献类型：
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作者：
MALPAS, SC;NINOMIYA, I
我们应用了一个计算机化的峰值检测算法记录同步的交感神经放电麻醉猫检索信息的特点，肾神经活动（RNA）在压力感受器活动的变化。该算法扫描了一系列RNA电压，以确定电压值的小簇中的显著增加，然后是显著降低。一旦检测到每个同步RNA峰，就计算其相应的幅度、宽度和峰-峰间隔。峰-峰间期的周期性显示了两种同步放电模式，一种在200-500 ms之间占间期的47%，另一种较高的20-180 ms频率（占间期的49%）。压力感受器刺激降低了高频的出现，同时增加了低频成分的概率。随着血压的升高，每秒同步峰值的总体发生率线性下降到零。RNA的峰值幅度呈单峰分布，不受压力感受器刺激的影响，直到平均动脉压增加达到阈值（平均142 +/- 5 mmHg），然后迅速下降到零。去窦-主动脉迷走神经不影响峰高的分布。同步放电的宽度也是单峰的，平均为82 +/- 1 ms，并且在压力反射刺激期间几乎不变，与峰值振幅的变化平行，并且在高血压下降低。窦-主动脉迷走神经切断不影响同步宽度。在所有条件下，同步放电的周期性和幅度或宽度之间没有关系。结果表明，肾脏同步放电的周期和幅度似乎是相互独立的，并受到压力感受器输入的不同影响。
We applied a computerized peak detection algorithm to recordings of synchronized sympathetic nerve discharges from anesthetized cats to retrieve information about the characteristics of renal nerve activity (RNA) during changes in baroreceptor activity. The algorithm scanned the series of RNA voltages for significant increases followed by significant decreases in a small cluster of voltage values. Once each synchronized RNA peak had been detected, its corresponding amplitude, width and peak-to-peak interval were calculated. The peak-to-peak interval periodicity showed two modes of synchronized discharge, one between 200-500 ms accounting for 47% of intervals, and a higher 20-180 ms frequency (49% of intervals). Baroreceptor stimulation decreased the occurrence of the high frequencies while increasing the probability of the lower frequency components. The overall occurrence of synchronized peaks per second fell linearly to zero with increases in blood pressure. The peak amplitude of RNA was unimodally distributed and was not affected by baroreceptor stimulation until an increase in mean arterial pressure reached a threshold (mean 142 +/- 5 mmHg) whereupon it fell quickly to zero. Sino-aortic vagal denervation did not affect the distribution of peak height. The width of synchronized discharges was also unimodal, mean 82 +/- 1 ms, and was almost unchanged during baroreflex stimulation acting in parallel with changes in the peak amplitude and decreasing at high blood pressures. Sino-aortic vagal denervation did not affect the synchronized width. There was no relationship between the periodicity and amplitude or width of synchronized discharges under all conditions. The results indicate that the periodicity and amplitude of renal synchronized discharges appear to be independent of each other and are differentially affected by baroreceptor input.