Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease
复制标题
DOI：
10.1164/rccm.2105106
复制
发表时间：
2002-05-15
影响因子：
24.7
通讯作者：
Barnes, PJ
中科院分区：
文献类型：
--
作者：
Culpitt, SV;de Matos, C;Barnes, PJ
慢性阻塞性肺疾病（COPD）的特征是嗜酸性气道炎症，可通过检查诱导痰来证实。茶碱在哮喘中有副作用，在本研究中，我们调查了低剂量茶碱治疗的COPD患者是否有类似的作用。25例COPD患者采用安慰剂对照、随机、双盲、交叉研究，用茶碱（血药浓度9-11 mg/L）治疗4周。茶碱耐受性良好。茶碱可使诱导痰炎性细胞、中性粒细胞、白细胞介素-8、髓过氧化物酶和乳铁蛋白均显着减少约22%。接受茶碱治疗的受试者的中性粒细胞对N-甲酰基-甲硫氨酸-亮氨酸-苯丙氨酸（与28%相似）和白细胞介素-8（与60%相似）的趋化性降低。一名健康供者的中性粒细胞对茶碱治疗期间获得的诱导痰样本的趋化性降低（接近30%）。这些结果表明，茶碱具有可用于COPD长期治疗的稳定性。
Chronic obstructive pulmonary disease (COPD) is characterized by a neutrophilic airway inflammation that can be demonstrated by examination of induced sputum. Theophylline has antiinflammatory effects In asthma, and in the present study we investigated whether a similar effect occurs in COPD patients treated with low doses of theophylline. Twenty-five patients with COPD were treated with theophylline (plasma level of 9-11 mg/L) for 4 weeks in a placebo-controlled, randomized, double-blind crossover study. Theophylline was well tolerated. Induced sputum inflammatory cells, neutrophils, interleukin-8, myeloperoxidase, and lactoferrin were all significantly reduced by about 22% by theophylline. Neutrophils from subjects treated with theophylline showed reduced chemotaxis to N-formyl-met-leu-phe (similar to28%) and interleukin-8 (similar to60%). Neutrophils from a healthy donor showed reduced chemotaxis (similar to30%) to induced sputum samples obtained during theophylline treatment. These results suggest that theophylline has antiinflammatory properties that may be useful in the long-term treatment of COPD.