Effects of hypoxic-ischemic encephalopathy and whole-body hypothermia on neonatal auditory function: a pilot study.
Effects of hypoxic-ischemic encephalopathy and whole-body hypothermia on neonatal auditory function: a pilot study.
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缺氧缺血性脑病和全身低温对新生儿听觉功能的影响：一项初步研究。
DOI：
10.1055/s-0028-1083842
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发表时间：
2008
影响因子：
2
通讯作者：
Lasky,RobertE
中科院分区：
文献类型：
--
作者：
Mietzsch,Ulrike;Parikh,NehalA;Williams,AmberL;Shankaran,Seetha;Lasky,RobertE
我们评估了缺氧缺血性脑病（HIE）和全身低温治疗对听觉脑干诱发反应（ABRs）和畸变产物耳声发射（dpoae）的影响。我们对中度或重度HIE新生儿的abr和dpoae进行了系列评估，随机分为低温治疗组（n= 4）和常规治疗组（n= 5）。参与者为5名男孩和4名女孩，平均胎龄（标准差）为38.9（1.8）周。在出生的第一周，通过dpoae测量的外周听觉功能在所有9名受试者中都被破坏了。abr延迟，但中枢传递完整，提示外周而非中枢神经损伤。3周龄时，外周听觉功能恢复正常。低温暂时延长了ABR，对于脑干中产生的更高的波来说更是如此，但在恢复体温时，效果很快就会逆转。新生儿听力测试是可行的，无创的，并且能够增强我们对HIE和低温对听觉功能影响的理解。
We assessed the effects of hypoxic-ischemic encephalopathy (HIE) and whole-body hypothermia therapy on auditory brain stem evoked responses (ABRs) and distortion product otoacoustic emissions (DPOAEs). We performed serial assessments of ABRs and DPOAEs in newborns with moderate or severe HIE, randomized to hypothermia (n= 4) or usual care (n= 5). Participants were five boys and four girls with mean gestational age (standard deviation) of 38.9 (1.8) weeks. During the first week of life, peripheral auditory function, as measured by the DPOAEs, was disrupted in all nine subjects. ABRs were delayed but central transmission was intact, suggesting a peripheral rather than a central neural insult. By 3 weeks of age, peripheral auditory function normalized. Hypothermia temporarily prolonged the ABR, more so for waves generated higher in the brain stem but the effects reversed quickly on rewarming. Neonatal audiometric testing is feasible, noninvasive, and capable of enhancing our understanding of the effects of HIE and hypothermia on auditory function.