Virilizing ovarian tumor in a 14-year-old female with a prior familial multinodular goiter
Virilizing ovarian tumor in a 14-year-old female with a prior familial multinodular goiter
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DOI：
10.1002/pbc.21675
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发表时间：
2008-10-01
影响因子：
3.2
通讯作者：
Niedziela, Marek
中科院分区：
文献类型：
--
作者：
Niedziela, Marek
患者女，14岁，因间歇性腹痛、嗓音低沉、闭经4个月就诊。12个月前，她因家族性多结节性甲状腺肿接受了甲状腺切除术，随后接受了L-甲状腺素替代治疗。入院时，检测到高血清睾酮水平。地塞米松抑制试验证实了激素自主性和磁共振成像（MRI）可视化的实体瘤内的左卵巢。左输卵管卵巢切除术后病理诊断为睾丸支持-间质细胞瘤。患者已无病6年。
A 14-year-old female presented with intermittent abdominal pain, deepening of voice and amenorrhoea for 4 months. Twelve months earlier she had had a thyroidectomy because of familial multinodular goiter and had, subsequently, received substitution with L-thyroxine. At the time of admission, a high serum testosterone level was detected. The dexamethasone suppression test confirmed the hormonal autonomy and magnetic resonance imaging (MRI) visualized a solid tumor within the left ovary. The pathological diagnosis after left salpingo-oophorectomy was Sertoli-Leydig cell tumor. The patient has remained disease-free for 6 years.