ALZHEIMERS AND PARKINSONS-DISEASE - BRAIN LEVELS OF GLUTATHIONE, GLUTATHIONE DISULFIDE, AND VITAMIN-E
ALZHEIMERS AND PARKINSONS-DISEASE - BRAIN LEVELS OF GLUTATHIONE, GLUTATHIONE DISULFIDE, AND VITAMIN-E
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DOI：
10.1007/bf03159937
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发表时间：
1991-06-01
期刊：
影响因子：
--
通讯作者：
MILLER, CA
中科院分区：
文献类型：
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作者：
ADAMS, JD;KLAIDMAN, LK;MILLER, CA
在神经正常对照患者和两组神经退行性疾病患者（阿尔茨海默病（AD）患者和伴有帕金森病（AD- pd）某些特征的AD患者）中测量了人脑谷胱甘肽（GSH）、谷胱甘肽二硫醚（GSSG）和维生素E的水平。对照脑样本中谷胱甘肽的含量比GSSG高50多倍。尾状核中谷胱甘肽水平最高，髓质中最低。在AD或AD- pd患者中，海马GSH水平显著高于对照组。与正常人相比，AD患者中脑GSH水平也较高。相比之下，AD-PD患者在该部位的GSH水平没有明显升高。在对照组和患病患者之间，GSSG水平在任何脑区都没有显著差异。在对照组大脑中，髓质比大脑其他区域含有更高水平的维生素E。尾状核的水平最低，大约是髓质水平的一半。中脑中维生素E的控制水平约为18.8 μ g/g。阿尔茨海默病患者的中脑维生素E水平翻了一番，达到42.3 μ g/g。AD-PD患者的中脑维生素E水平也增加了一倍，达到44.0 μ g/g。这些结果可能表明，在AD或AD- pd患者的特定脑区受损后，GSH和维生素E水平的代偿性增加发生。
Human brain levels of glutathione (GSH), glutathione disulfide (GSSG), and vitamin E were measured in neurologically normal control patients and two groups of patients with neurodegeneration: those with Alzheimer's disease (AD), and AD with some features of Parkinson's disease (AD-PD). Control brain samples contained GSH levels more than 50 times higher than GSSG. The levels of GSH were highest in the caudate nucleus and lowest in the medulla. In patients with AD or AD-PD, hippocampal levels of GSH were significantly higher than controls. Patients with AD also demonstrated high GSH levels in the midbrain compared to normal. In contrast, patients with AD-PD did not have significantly elevated GSH levels in this site. GSSG levels were not significantly different in any brain region between controls and diseased patients. In control brains, the medulla had higher levels of vitamin E than any other brain region. The caudate nucleus had the lowest levels, which were about half the levels in the medulla. Control levels of vitamin E in the midbrain were about 18.8-mu-g/g. In AD patients the midbrain levels of vitamin E doubled to 42.3-mu-g/g. This doubling also occurred in AD-PD patients where midbrain vitamin E levels increased to 44.0-mu-g/g. These results may indicate that compensatory increases in GSH and vitamin E levels occur following damage to specific brain regions in patients with AD or AD-PD.