Increased prevalence of cigarette smoking in Japanese patients with sarcoidosis
Increased prevalence of cigarette smoking in Japanese patients with sarcoidosis
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DOI：
10.1111/resp.12153
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发表时间：
2013-10-01
期刊：
影响因子：
6.9
通讯作者：
Nishimura, Masaharu
中科院分区：
文献类型：
--
作者：
Hattori, Takeshi;Konno, Satoshi;Nishimura, Masaharu
背景和目的一些研究表明，在西方人群中，结节病患者在诊断前吸烟的可能性较小。结节病的流行病学特征在日本人和西方人之间是不同的。因此，吸烟和结节病之间的关系在日本populations.MethodsThree 88例新诊断的结节病2000年和2008年之间进行了回顾性研究。日本两次大规模吸烟流行率调查的结果提供了参考数据。结节病的具体临床表现进行了比较，目前吸烟者和从不吸烟者，排除前smokers.ResultsThe目前吸烟者的患病率在结节病的诊断时，男性为59.6%，女性为27.9%。除30多岁的男性外，所有年龄组的患病率均高于日本普通人群。目前吸烟者肺实质受累的患病率往往高于从不吸烟者（比值比=1.33（0.99-1.77），P=0.054）结论这项回顾性队列研究表明，日本结节病患者的吸烟率高于西方结节病患者，在这些患者中，吸烟与结节病的发生之间可能存在不同的关系。人口。
Background and objectiveSeveral studies have shown that individuals with sarcoidosis in Western populations are less likely to have smoked before diagnosis. Epidemiological characteristics of sarcoidosis are known to differ between Japanese and Westerners. Therefore, the relationship between cigarette smoking and sarcoidosis in a Japanese population was investigated.MethodsThree hundred eighty-eight patients newly diagnosed with sarcoidosis between 2000 and 2008 were retrospectively identified. The results of two large surveys of smoking prevalence in Japan provided reference data. Specific clinical manifestations of sarcoidosis were compared between current smokers and never-smokers, after excluding former smokers.ResultsThe prevalence of current smokers at the time of the diagnosis of sarcoidosis was 59.6% in men and 27.9% in women. With the exception of men in their 30s, the prevalence was higher in all age groups compared with the general Japanese population. The prevalence of lung parenchymal involvement tended to be higher in current smokers than in never-smokers (odds ratio=1.33 (0.99-1.77), P=0.054).ConclusionsThis retrospective cohort study suggests that smoking prevalence is higher in Japanese sarcoidosis patients than that reported in Western sarcoidosis patients and that there could be different relationships between smoking and the development of sarcoidosis in these populations.