TREFOIL PEPTIDE PROTECTION OF INTESTINAL EPITHELIAL BARRIER FUNCTION - COOPERATIVE INTERACTION WITH MUCIN GLYCOPROTEIN
TREFOIL PEPTIDE PROTECTION OF INTESTINAL EPITHELIAL BARRIER FUNCTION - COOPERATIVE INTERACTION WITH MUCIN GLYCOPROTEIN
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DOI：
10.1016/0016-5085(95)90340-2
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发表时间：
1995-08-01
期刊：
影响因子：
29.4
通讯作者：
PODOLSKY, DK
中科院分区：
文献类型：
--
作者：
KINDON, H;POTHOULAKIS, C;PODOLSKY, DK
背景和目的：杯状细胞分泌三叶肽和粘蛋白糖蛋白的组合，在粘膜表面形成连续的凝胶。这些产品的功能效果仍不确定。方法：将三叶肽和/或粘蛋白糖蛋白添加到人结肠癌衍生的 T84 细胞系的 Transwell 单层中。完整的单分子层允许渗透
Background and Aims: Goblet cells secrete a combination of trefoil peptides and mucin glycoproteins to form a continuous gel on the mucosal surface. The functional effects of these products remain uncertain. Methods: Trefoil peptides and/or mucin glycoproteins were added to Transwell monolayers of the human colonic cancer-derived T84 cell line. Intact monolayers permitted penetration of