Solution phase synthesis of libraries of variably substituted olefin scaffolds: A library of allylic amines
Solution phase synthesis of libraries of variably substituted olefin scaffolds: A library of allylic amines
复制标题
DOI：
10.1021/cc0000601
复制
发表时间：
2001-01-01
影响因子：
--
通讯作者：
Siegel, MG
中科院分区：
文献类型：
--
作者：
Organ, MG;Mayhew, D;Siegel, MG
描述了源自烯烃模板的烯丙胺库的合成。两步溶液相反应顺序包括模板的胺化、随后的 Suzuki 偶联以及通过离子交换色谱法的快速纯化。该方法已用于合成 1344 个成员的烯丙胺库。
The synthesis of allylic amine libraries derived from olefin templates is described. The two-step, solution phase reaction sequence consists of amination of the template followed by Suzuki coupling and expedited purification via ion exchange chromatography. The methodology has been used to synthesize a 1344-member allylic amine library.