CARBAMYL PHOSPHATE SYNTHESIS IN EARTHWORM LUMBRICUS TERRESTRIS
CARBAMYL PHOSPHATE SYNTHESIS IN EARTHWORM LUMBRICUS TERRESTRIS
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DOI：
10.1126/science.142.3599.1583
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发表时间：
1963-01-01
期刊：
影响因子：
56.9
通讯作者：
CAMPBELL, JW
中科院分区：
文献类型：
--
作者：
BISHOP, SH;CAMPBELL, JW
瓜氨酸的酶促合成来自氨、碳酸氢盐、三磷酸腺苷和L-鸟氨酸，发生在蚯蚓肠道组织的可溶部分。合成发生在低氨浓度下，取决于添加的N-乙酰基-L-谷氨酸盐，并导致碳酸氢盐碳掺入瓜氨酸分子的脲基中。磷酸氨甲酰是反应的中间体，其在脊椎动物中的生物合成是由类似于排脲脊椎动物的磷酸氨甲酰合成酶系统介导的。
The enzymatic synthesis of citrulline from ammonia, bicarbonate, adenosine triphosphate, and L-ornithine takes place in the soluble fraction of gut tissue of the earthworm. The synthesis occurs at low ammonia concentrations, is dependent upon added N-acetyl-L-glutamate, and results in incorporation of the bicarbonate carbon into the ureido group of the citrulline molecule. Carbamyl phosphate is the intermediate in the reaction and its biosynthesis in the earthworm is mediated by a carbamyl phosphate synthetase system similar to that of ureotelic vertebrates.