ACTIVATION OF TRIGEMINAL BRAIN-STEM NOCICEPTIVE NEURONS BY DURAL ARTERY STIMULATION
ACTIVATION OF TRIGEMINAL BRAIN-STEM NOCICEPTIVE NEURONS BY DURAL ARTERY STIMULATION
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DOI：
10.1016/0304-3959(86)90244-7
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发表时间：
1986-06-01
期刊：
影响因子：
7.4
通讯作者：
DOSTROVSKY, JO
中科院分区：
文献类型：
--
作者：
DAVIS, KD;DOSTROVSKY, JO
血管性头痛被认为是由支配颅血管的三叉神经感觉神经纤维的激活引起的。支持这一假设的搜索在三叉神经脑干尾侧亚核（SNC）的电刺激脑膜中动脉（MMA）引起的神经元反应。发现78个SNC神经元可以被MMA刺激兴奋，在详细研究的40个神经元中，88%也被面部皮肤的伤害性刺激兴奋。这些结果提供了第一份报告的存在和功能特性的脑干神经元可能参与介导血管性头痛。
Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery (MMA). Seventy-eight SNC neurons were found which could be excited by MMA stimulation and of the 40 neurons studied in detail, 88% were also excited by noxious stimulation of the facial skin. These results provide the first report of the existence and functional properties of brain-stem neurons likely to be involved in mediating vascular head pain.