ALTERATION OF COAGULATION MECHANISMS IN ENVENOMATION BY BOTHROPS-ASPER (VELVET)
ALTERATION OF COAGULATION MECHANISMS IN ENVENOMATION BY BOTHROPS-ASPER (VELVET)
复制标题
DOI：
10.1016/0041-0101(85)90024-8
复制
发表时间：
1985-01-01
期刊：
影响因子：
2.8
通讯作者：
BOLANOS, R
中科院分区：
文献类型：
--
作者：
BARRANTES, A;SOLIS, V;BOLANOS, R
18名被B咬伤患者的血液。研究了asper对混凝的影响。所有的纤维蛋白原和因子II，V，VIII，IX，X和XI的水平，以及抗凝血酶-III和纤溶酶原的变化。与对照组相比，血小板数量和因子VII和因子XII的浓度未显示出显著变化。纤维蛋白原的生物测定，定量的纤维蛋白原降解产物和因子II，和一般的凝血试验，如凝血酶原和部分凝血活酶时间，显示出良好的相关性与严重程度的envenomation。被B蛇咬了一旦出现严重的低纤维蛋白原血症，伴随着纤维蛋白溶解系统的激活引起的纤维蛋白降解以及因子II的激活和消耗。静脉注射少量抗蛇毒血清进行紧急治疗并不能阻止上述凝血功能的改变。
Blood from 18 patients bitten by B. asper were studied for effects on coagulation. All showed alterations in the levels of fibrinogen and of factors II, V, VIII, IX, X and XI, as well as in anti-thrombin-III and plasminogen. The number of platelets and the concentrations of factors VII and XII did not show significant variations in comparison with the controls. The biological assay of fibrinogen, the quantitation of fibrinogen degradation products and of factor II, and the general coagulation tests, such as prothrombin and partial thromboplastin times, showed a good correlation with the severity of the envenomation. In snakebites by B. asper there is a severe hypofibrinogenemia, with fibrin degradation by activation in the fibrinolytin system and with activation and consumption of factor II. I.v. emergency treatment with small quantities of antivenom did not prevent the above noted alterations in coagulation.