A cautionary note on the power of the test for the indirect effect in mediation analysis.
A cautionary note on the power of the test for the indirect effect in mediation analysis.
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DOI：
10.3389/fpsyg.2014.01549
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发表时间：
2014
影响因子：
3.8
通讯作者：
Vansteelandt S
中科院分区：
文献类型：
--
作者：
Loeys T;Moerkerke B;Vansteelandt S
最近的模拟研究表明，即使存在直接效应，中介效应检验的功效也比总效应检验的功效更高。这促使应用研究人员在没有证据表明总体效果的情况下研究调解。在本文中，我们提供了对在没有直接效应的情况下可以预期中介效应检验与总效应检验相比更高功效的情况的分析见解。我们认为，广受好评的功率增益具有一定的欺骗性，而且代价高昂。根据结果，我们建议，当主要兴趣仅在于中介时，不应将总效应的显着性检验作为间接效应检验的先决条件。然而，由于当未测量或不考虑中介因素和结果的常见原因时，间接效应的检验很容易出现偏差，因此应在敏感性分析中对其进行评估。
Recent simulation studies have pointed to the higher power of the test for the mediated effect vs. the test for the total effect, even in the presence of a direct effect. This has motivated applied researchers to investigate mediation in settings where there is no evidence of a total effect. In this paper we provide analytical insight into the circumstances under which higher power of the test for the mediated effect vs. the test for the total effect can be expected in the absence of a direct effect. We argue that the acclaimed power gain is somewhat deceptive and comes with a big price. On the basis of the results, we recommend that when the primary interest lies in mediation only, a significant test for the total effect should not be used as a prerequisite for the test for the indirect effect. However, because the test for the indirect effect is vulnerable to bias when common causes of mediator and outcome are not measured or not accounted for, it should be evaluated in a sensitivity analysis.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1023/a:1026595011371
发表时间：
2000-12-01
期刊：
Prevention science : the official journal of the Society for Prevention Research
影响因子：
--
作者：
MacKinnon, D P;Krull, J L;Lockwood, C M
通讯作者：
Lockwood, C M
影响因子：
7
作者：
Imai, Kosuke;Keele, Luke;Tingley, Dustin
通讯作者：
Tingley, Dustin
影响因子：
3.8
作者：
Fritz MS;Taylor AB;Mackinnon DP
通讯作者：
Mackinnon DP
影响因子：
8.2
作者：
Fritz, Matthew S.;MacKinnon, David P.
通讯作者：
MacKinnon, David P.