Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats
Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats
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DOI：
10.1254/jjp.75.443
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发表时间：
1997-12-01
期刊：
影响因子：
--
通讯作者：
Watanabe, H
中科院分区：
文献类型：
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作者：
Murakami, Y;Tanaka, E;Watanabe, H
采用8臂和4臂放射状迷宫实验，观察了胆碱酯酶抑制剂他克林（tacrine）对永久性阻断双侧颈总动脉（2 VO）所致大鼠空间获得障碍的影响。每天给药他克林（0.1和0.3 mg/kg，i. p.）2 VO术后1个月，常规迷宫任务中受损的空间获得明显改善。这种治疗也改善了2 VO诱导的工作，但不是参考记忆缺陷的4臂诱饵径向迷宫任务。这些结果提示，他克林改善2 VO大鼠的工作记忆障碍是通过刺激中枢胆碱能系统实现的。
Effect of tacrine, a cholinesterase inhibitor, on spatial acquisition deficit caused by permanent occlusion of bilateral common carotid arteries (2VO) was examined by using the conventional 8-arm and the 4-arm baited radial maze tasks in rats. Daily administration of tacrine (0.1 and 0.3 mg/kg, i.p.) 1 month after 2VO operation significantly improved the impaired spatial acquisition in the conventional maze task. This treatment also ameliorated the 2VO-induced working but not reference memory deficit in the 4-arm baited radial maze task. These results suggest that tacrine improvement of working memory deficit in the 2VO rats is due to stimulation of central cholinergic systems.