Inhibition of proteases in coagulation, kinin-forming and complement systems by alpha2-plasmin inhibitor.
Inhibition of proteases in coagulation, kinin-forming and complement systems by alpha2-plasmin inhibitor.
复制标题
α2-纤溶酶抑制剂抑制凝血、激肽形成和补体系统中的蛋白酶。
DOI：
10.1093/oxfordjournals.jbchem.a131801
复制
发表时间：
1977
影响因子：
2.7
通讯作者：
N. Aoki
中科院分区：
文献类型：
--
作者：
M. Moroi;N. Aoki
研究了α 2-纤溶酶抑制剂对各种蛋白酶的抑制活性。该抑制剂迅速抑制α-糜蛋白酶的酯水解活性，并逐步抑制牛血浆激肽释放酶、牛凝血酶和牛活化因子X的酯水解或酰胺水解活性。肝素对抑制剂与凝血酶或活化的因子X的反应没有影响。但对人C-1-酯酶、木瓜蛋白酶和蛇毒激肽原酶活性无影响。基于其对激肽释放酶的快速抑制作用，α 2-纤溶酶抑制剂被认为对血浆中的激肽释放酶活性具有一定的调节作用。
Inhibitory activities of alpha2-plasmin inhibitor against various proteases were investigated. The inhibitor promptly inhibited the esterolytic activity of alpha-chymotrypsin and progressively inhibited the esterolytic or amidolytic activities of bovine plasma kallikrein, bovine thrombin and bovine activated factor X. Heparin had no effect on the reaction of the inhibitor with thrombin or activated factor X. However, the inhibitor had no effect on the activities of human C-1-esterase, papain and snake venom kininogenase. On the basis of its rapid inhibition of kallikrein, alpha2-plasmin inhibitor is considered to exert some regulating effect on kallikrein activity in plasma.