Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats
Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats
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早期适度运动通过改善大鼠炎症和心室重塑，有利于心肌梗死的愈合
DOI：
10.1111/jcmm.14710
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发表时间：
2019-10-15
影响因子：
5.3
通讯作者：
Cai, Dongqing
中科院分区：
文献类型：
--
作者：
Liao, Zhaofu;Li, Dan;Cai, Dongqing
到目前为止，与早期（特别是在急性心肌梗死（MI）后24小时内）运动介导的对MI的有益作用相关的细胞和分子机制尚未完全建立。在本研究中，我们证明了在MI后一天开始进行早期适度运动训练的急性MI大鼠的死亡率没有增加，并且在MI愈合和心室重塑方面显示出显著改善，包括心脏功能的改善，梗死面积的减少，心肌细胞凋亡，心脏纤维化和心肌细胞肥大，以及心肌血管生成的增加，左心室壁厚度和边缘区的心脏端细胞数量。通过独创性途径分析系统进行的整合miRNA-mRNA谱分析显示，TGFB 1调控网络的抑制、白细胞的活化和白细胞向梗死区的迁移构成了早期中度运动介导的心脏纤维化和病理性炎症反应改善的分子机制。本研究的结果表明，MI后一天开始的早期适度运动训练是安全的，并可显著增强MI愈合和心室重塑。了解这种早期训练方案的积极作用背后的机制将有助于我们进一步为人类量身定制合适的心脏康复计划。
Thus far, the cellular and molecular mechanisms related to early (especially within 24 hours after acute myocardial infarct (MI)) exercise-mediated beneficial effects on MI have not yet been thoroughly established. In the present study, we demonstrated that acute MI rats that underwent early moderate exercise training beginning one day after MI showed no increase in mortality and displayed significant improvements in MI healing and ventricular remodelling, including an improvement in cardiac function, a decrease in infarct size, cardiomyocyte apoptosis, cardiac fibrosis and cardiomyocyte hypertrophy, and an increase in myocardial angiogenesis, left ventricular wall thickness and the number of cardiac telocytes in the border zone. Integrated miRNA-mRNA profiling analysis performed by the ingenuity pathway analysis system revealed that the inhibition of the TGFB1 regulatory network, activation of leucocytes and migration of leucocytes into the infarct zone comprise the molecular mechanism underlying early moderate exercise-mediated improvements in cardiac fibrosis and the pathological inflammatory response. The findings of the present study demonstrate that early moderate exercise training beginning one day after MI is safe and leads to significantly enhanced MI healing and ventricular remodelling. Understanding the mechanism behind the positive effects of this early training protocol will help us to further tailor suitable cardiac rehabilitation programmes for humans.