Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.
Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.
复制标题
重复的轻度外伤性脑损伤会导致侧隔和海马的局灶性反应。
DOI：
10.2217/cnc-2015-0001
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
Conover JC
中科院分区：
文献类型：
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作者：
Acabchuk R;Briggs DI;Angoa-Pérez M;Powers M;Wolferz R Jr;Soloway M;Stern M;Talbot LR;Kuhn DM;Conover JC
为了促进我们对重复轻度创伤性脑损伤（rmTBI）的区域和时间细胞反应的理解，我们使用了rmTBI的小鼠模型，该模型包括加速，减速和旋转力。使用改良的重量下降法来比较两种损伤间间隔，rmTBI-短（在3天内递送5次撞击）和rmTBI-长（在15天内递送5次撞击）。在伤后三个时间点（即刻、2周和6周）对前脑和中脑组织学变化进行了区域研究。rmTBI-短协议产生了立即的，本地化的小胶质细胞和星形胶质细胞的反应，在背外侧隔和海马，与星形胶质细胞的反应持续在背外侧隔。rmTBI-long方案仅显示背外侧隔中的短暂星形胶质细胞反应。我们的研究结果表明，外侧隔和海马是特别脆弱的区域在rmTBI，可能有助于记忆和情感障碍与反复脑震荡。
To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces. A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological alterations were performed at three post-injury time points (immediate, 2 weeks and 6 weeks). The rmTBI-short protocol generated an immediate, localized microglial and astroglial response in the dorsolateral septum and hippocampus, with the astroglial response persisting in the dorsolateral septum. The rmTBI-long protocol showed only a transitory astroglial response in the dorsolateral septum. Our results indicate that the lateral septum and hippocampus are particularly vulnerable regions in rmTBI, possibly contributing to memory and emotional impairments associated with repeated concussions.