OBSERVATIONS ON THE PATHOGENESIS OF EXPERIMENTAL SALMONELLA-TYPHIMURIUM INFECTION IN CHICKENS
OBSERVATIONS ON THE PATHOGENESIS OF EXPERIMENTAL SALMONELLA-TYPHIMURIUM INFECTION IN CHICKENS
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DOI：
10.1016/s0034-5288(18)30685-4
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发表时间：
1987-03-01
影响因子：
2.4
通讯作者：
SIMPSON, JM
中科院分区：
文献类型：
--
作者：
BARROW, PA;HUGGINS, MB;SIMPSON, JM
对鼠伤寒沙门氏菌菌株进行了毒力测定。口服接种后的死亡率从0到100%不等，有些品种比其他品种更敏感。口服和胃肠外毒力之间没有相关性。与一种毒性最强的菌株有关的发病机制研究表明，入侵后，生物体在肝脏和脾脏中繁殖，并扩散到其他器官，产生全身感染。死亡原因可能是厌食症和全身不适和腹泻引起的脱水。经过详细研究的强毒株在体内传播的速度更快，持续的时间更长，而且比无毒毒株更具侵袭性。在所研究的系统中，入侵性是最重要的毒力决定因素。
The virulence of Salmonella typhimurium strains for day-old chickens was examined. The mortality following oral inoculation varied from 0 to 100 per cent. Some breeds were more susceptible than others. There was no correlation between oral and parenteral virulence. Pathogenesis studies associated with one of the most virulent strains suggested that, after invasion, organisms multiplied in the liver and spleen and spread to other organs producing a systemic infection. The cause of death was probably a combination of anorexia and dehydration resulting from general malaise and diarrhoea. A virulent strain studied in detail spread through the body faster, persisted for a longer period and was more invasive than an avirulent strain. In the system studied invasiveness was the virulence determinant of overriding importance.