Circulating digitalis-like compounds in essential hypertension.
Circulating digitalis-like compounds in essential hypertension.
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原发性高血压中循环洋地黄样化合物。
DOI：
10.3109/10641968409062576
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
P. Meyer
中科院分区：
文献类型：
--
作者：
M. Devynck;M. Pernollet;J. Cloix;H. de Thé;L. Kamal;J. Elghozi;J. Rosenfeld;P. Meyer
Na+泵抑制剂已被认为参与钠排泄、细胞外液调节和血压升高。通过在4项试验中比较血浆提取物与哇巴因的作用，研究了人血浆中洋地黄样化合物的存在。- 与哇巴因竞争结合Na+泵，-抑制Na+和K+依赖性水解-抑制人血小板对5-羟色胺的摄取-中枢高血压效应血浆组分在4个试验中表现出洋地黄样性质。比较了42例正常血压者（21例有高血压家族史）、38例原发性高血压患者（15例接受降压治疗）和9例慢性肾功能衰竭患者血浆提取物的作用。40%未经治疗的高血压患者和高血压遗传性血压正常者的血浆具有高抑制水平。β受体阻滞剂治疗患者的抑制增强，而利尿剂治疗患者的抑制降低。在尿毒症血浆中未观察到洋地黄样活性。这些观察结果强烈表明人血浆中存在洋地黄样化合物，并指出其可能与高血压相关。
Inhibitors of the Na+ pump have been proposed as participating in sodium excretion, extracellular fluid regulation, and in the rise of blood pressure. The presence of digitalis-like compounds in human plasma has been investigated by comparing the effects of plasma extracts to those of ouabain in 4 tests. - competition with ouabain for binding to the Na+ pump, - inhibition of Na+ and K+ dependent hydrolysis - inhibition of serotonin uptake by human platelets - central hypertensive effect Plasma fractions exhibited digitalis-like properties in the 4 tests. The effects of plasma extracts of 42 normotensive subjects (21 with family history of hypertension) and 38 patients with essential hypertension (15 with antihypertensive treatment) and 9 patients with chronic renal failure were compared. Plasma from Forty per cent of untreated hypertensive patients and normotensives with hypertensive heredity had a high inhibition level. Inhibition was enhanced in beta-blocker treated patients and decreased in those on diuretics. No digitalis-like activity was observed in uremic plasma. These observations strongly suggest the presence of digitalis-like compound(s) in human plasma and point to its possible association with hypertension.