Practical application of the new classification scheme for congenital melanocytic nevi.
Practical application of the new classification scheme for congenital melanocytic nevi.
复制标题
先天性黑素细胞痣新分类方案的实际应用。
DOI：
10.1111/pde.12428
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发表时间：
2015
影响因子：
1.5
通讯作者：
Krengel,Sven
中科院分区：
文献类型：
--
作者：
Price,HarperN;O'Haver,Judith;Marghoob,Ashfaq;Badger,Kellie;Etchevers,Heather;Krengel,Sven
最近提出了一种新的基于共识的先天性黑素细胞痣（CMN）分类。它包括预计成人尺寸 (PAS) 和位置、卫星痣计数和形态特征（颜色异质性、粗糙度、结节性和多毛症）的类别。当前研究的目的是测试新分类方案的适用性，并将分类结果与患者的黑色素瘤和神经皮肤黑色素细胞增多症 (NCM) 病史相关联。参加 2012 年在德克萨斯州达拉斯举行的患者会议的 CMN 儿童和成人被邀请参加这项研究。使用标准化问卷收集历史数据。两名皮肤科医生进行了临床检查。在入组的 45 名患者中，33 名患有巨大 CMN（G1 [>40 cm PAS]，n= 13；G2 [>60 cm PAS]，n= 20），12 名患有 NCM（5 名有症状，7 名无症状），1 名有黑色素瘤病史。 CMN 大小与 NCM 呈正相关 (p < 0.05)。该分类系统可以对每个单独的 CMN 进行简单而详细的表型表征。手术切除后患者的 CMN 大小和形态很难评估，出生时或婴儿期卫星痣的数量并不总是已知。我们的报告为新提出的 CMN 分类的应用提供了实用的帮助。对 CMN 登记处准确分类的患者进行前瞻性评估将揭示该方案的预测价值。研究样本较小，限制了有关 CMN 参数与 NCM 和黑色素瘤风险之间相关性的有意义的结论。
A new consensus‐based classification of congenital melanocytic nevi (CMN) has recently been proposed. It includes categories for projected adult size (PAS) and location, satellite nevi counts, and morphologic characteristics (color heterogeneity, rugosity, nodularity, and hypertrichosis). The objective of the current study was to test the applicability of the new categorization scheme and to correlate classification outcome with the patient's history of melanoma and neurocutaneous melanocytosis (NCM). Children and adults with CMN attending a patient conference in Dallas, Texas, in 2012 were invited to participate in the study. Anamnestical data were collected using a standardized questionnaire. Two dermatologists performed clinical examinations. Of 45 patients enrolled, 33 had a giant CMN (G1 [>40 cm PAS],n= 13; G2 [>60 cm PAS],n= 20), 12 had an NCM (5 symptomatic, 7 asymptomatic), and 1 had a history of melanoma. CMN size was positively correlated with NCM (p < 0.05). The classification system allowed an easy and detailed phenotypic characterization of each individual CMN. CMN size and morphology were difficult to assess in patients after surgical removal, and the number of satellite nevi at birth or during infancy was not always known. Our report provides practical aids for the application of the newly proposed CMN classification. Prospective evaluation of accurately classified patients in CMN registries will reveal the predictive value of the scheme. The small study sample limits meaningful conclusions regarding the correlation between CMN parameters and the risk of NCM and melanoma.