Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics
Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics
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DOI：
10.1046/j.1525-1594.2001.025005341.x
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发表时间：
2001-05-01
影响因子：
2.4
通讯作者：
Reul, H
中科院分区：
文献类型：
--
作者：
Apel, J;Paul, R;Reul, H
在人工器官的预设计阶段对剪切诱导的溶血进行计算评估甚至量化（例如，心脏辅助装置）将大大减少设计和开发的努力和成本。在这篇文章中，通过计算流体动力学（CFD）的溶血分析的一般方法进行了讨论。采用一个经过验证的微轴血泵计算模型，对剪应力分布进行了详细分析。提出了几种方法，允许定性评估的剪切应力分布和相关的曝光时间使用拉格朗日方法和质量分布结合剪切应力分析。结果表明，计算流体力学提供了一个方便的工具，剪切诱导溶血的一般评估。的临界区域的确定和估计的血液的量受到潜在的损害，相对于总的质量流量被证明是可行的。然而，意识到基于CFD的溶血评估的局限性和潜在缺陷至关重要。
A computational assessment or even quantification of shear induced hemolysis in the predesign phase of artificial organs (e.g., cardiac assist devices) would largely decrease efforts and costs of design and development. In this article, a general approach of hemolysis analysis by means of computational fluid dynamics (CFD) is discussed. A validated computational model of a microaxial blood pump is used for detailed analysis of shear stress distribution. Several methods are presented that allow for a qualitative assessment of shear stress distribution and related exposure times using a Lagrangian approach and mass distribution in combination with shear stress analysis. The results show that CFD offers a convenient tool for the general assessment of shear-induced hemolysis. The determination of critical regions and an estimation of the amount of blood subject to potential damage in relation to the total mass flow are shown to be feasible. However, awareness of limitations and potential flaws in CFD based hemolysis assessments is crucial.