Stage IA uterine serous carcinoma - A study of 13 cases
Stage IA uterine serous carcinoma - A study of 13 cases
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DOI：
10.1097/00000478-199712000-00015
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发表时间：
1997-12-01
影响因子：
5.6
通讯作者：
Chambers, JT
中科院分区：
文献类型：
--
作者：
Carcangiu, ML;Tan, LK;Chambers, JT
虽然在类浆液性子宫内膜癌中，浸润深度是预测宫外病变和生存率的有力指标，但在浆液性子宫内膜癌中，其重要性尚不清楚。据报道，局限于子宫内膜或子宫内膜息肉的浆液性肿瘤患者会复发和死亡。然而，在其他研究中，没有子宫肌层浸润与更有利的过程相关。为了澄清这个问题，我们回顾了13例完全分期的IA期浆液性癌，随访时间为10 ~ 93个月（中位数38个月），其中进行了广泛的组织学检查。浆液性癌在6例子宫内膜息肉中被发现，在4例子宫内膜息肉和相关的子宫内膜中被发现，在3例仅在子宫内膜中被发现。没有其他组织学类型的子宫内膜癌，也没有子宫肌层浸润。多灶性浆液性上皮内癌12例。两名患者在出现后10个月和14个月死于腹腔内癌病。总体估计生存率为83%，显示相对良好的预后。总之，虽然组织学检测子宫肌层浸润的缺乏可能与浆液性癌的复发和死亡有关，但目前，基于仔细的组织学检查的准确评估的分期似乎是最可靠的生存预测因素。
Although in endometrioid type endometrial carcinoma depth of invasion is a powerful predictor of extrauterine disease and survival, in serous carcinoma its importance is unclear. Recurrences and death in patients with serous tumors confined to the endometrium or an endometrial polyp have been reported. In other studies, however, the absence of myometrial invasion was correlated with a more favorable course. In an attempt to clarify this issue, we reviewed 13 completely staged, stage IA serous carcinomas with follow-up from 10 to 93 months (median 38), in which extensive histologic examination had been performed. Serous carcinoma was identified in an endometrial polyp in six cases, in an endometrial polyp and associated endometrium in four, and solely in the endometrium in three cases. No other histologic types of endometrial carcinoma were present, and there was no myometrial invasion. Multifocal serous intraepithelial carcinoma was also seen in 12 cases. Two of the patients died of disease with intraabdominal carcinomatosis at 10 and 14 months after presentation. The overall estimated survival was 83%, showing a relatively favorable prognosis. In conclusion, although the absence of histologically detected myometrial invasion may be associated with recurrences and death in serous carcinoma, an accurately assessed stage based on a careful histologic examination appears to be, at present, the most reliable predictor of survival.