Cytokines and their role in the pathophysiology of osteoarthritis
Cytokines and their role in the pathophysiology of osteoarthritis
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DOI：
10.2741/martel
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发表时间：
1999-10-15
期刊：
影响因子：
--
通讯作者：
Pelletier, Jean-Pierre
中科院分区：
文献类型：
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作者：
Martel-Pelletier, Johanne;Alaaeddine, Nada;Pelletier, Jean-Pierre
骨关节炎（OA）病理过程的具体病因尚未确定，然而，临床阶段的偶发性炎症现在是一种有据可查的现象，并且被认为参与疾病进展。白细胞介素-1 β（IL-1 β）和肿瘤坏死因子-α（TNF-α）是OA过程中合成的主要促炎细胞因子。具有促炎特性或分解代谢因子的其他细胞因子也可能导致这种病理状况，并且具有促炎特性的那些细胞因子可能能够抵消前者对疾病过程的负面影响。在本章中，我们将审查细胞因子的相互作用和它们对关节组织代谢的调节作用，包括它们的刺激和/或抑制作用，以及它们与OA的潜在相关性。我们还将简要调查与细胞因子相关的主要生物学因素，这些因素对未来的治疗方法有希望。
The specific causative agent of the pathological process of osteoarthritis (OA) has not yet been identified, however, episodic inflammation at the clinical stage is now a well documented phenomenon and believed to be involved in the disease progression. Interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are the predominant proinflammatory cytokines synthesized during the OA process. Other cytokines having proinflammatory properties or catabolic factors could also contribute to this pathological condition, and those having antiinflammatory properties may be able to counteract the negative effects of the former on the disease process. In this chapter, we will review cytokine interactions and their modulatory effects on joint articular tissue metabolism, including their stimulatory and/or inhibitory actions, and their potential relevance to OA. We will also briefly survey the major biological factors, in relation to cytokines, that look promising for future therapeutic approaches.