Incidence of cancer and statin usage-record linkage study
Incidence of cancer and statin usage-record linkage study
复制标题
DOI：
10.1002/ijc.24536
复制
发表时间：
2010-01-01
影响因子：
6.4
通讯作者：
Tiihonen, Jari
中科院分区：
文献类型：
--
作者：
Haukka, Jari;Sankila, Risto;Tiihonen, Jari
他汀类药物（HMG-CoA还原酶抑制剂）的使用量一直在增加，相当一部分中老年人群持续使用。由于大部分人口受到辐射，即使是癌症风险略有增加也应予以考虑。我们在芬兰进行了一项记录关联研究，利用了全国范围内报销的他汀类药物和癌症的数据库。研究人群包括芬兰所有他汀类药物使用者，他们在1996年至2005年期间购买了至少一种处方药，并且在首次购买时没有癌症诊断。还包括未使用他汀类药物的对照人群。数据包括472，481对个体，累积420万人年，平均随访8.8年。观察了5294例癌症病例。辛伐他汀和阿托伐他汀是最常用的药物。最常见的癌症是前列腺癌、乳腺癌、肺癌、结肠癌和直肠癌。一般来说，他汀类药物的使用与癌症之间没有关联。总之，这项研究增加了关于他汀类药物使用与癌症发病率之间关系的大规模、基于人群的结果。我们发现他汀类药物的使用与癌症之间既没有有益的联系，也没有有害的联系。
The consumption of statins (HMG-CoA reductase inhibitors) has been increasing, and a substantial part of the middle-aged and elderly population use them continuously. Because a large fraction of the population is exposed, even a small excess of risk with respect to cancer should be considered. We carried out a record-linkage study in Finland utilizing nationwide databases of reimbursed statin medication and cancer. The study population included all statin users in Finland who had purchased at least 1 prescription between 1996 and 2005 and who had no cancer diagnosis at the date of first purchase. A control population without statin usage was also included. Data consisted of 472,481 pairs of individuals that cumulated 4.2 million person years with an average of 8.8 years of follow-up. Fifty thousand two hundred ninety-four cancer cases were observed. Simvastatin and atorvastatin were the most used substances. The most frequent cancers were prostate, breast, lung, colon, and rectum cancer. In general, no association between the utilization of statins and cancer could be detected. In conclusion, this study adds large-scale, population-based results about the association between statin utilization and the incidence of cancer. We found neither beneficial nor harmful associations between the usage of statins and cancer.