Aberrant interactions of cortical networks in chronic migraine A resting-state fMRI study
Aberrant interactions of cortical networks in chronic migraine A resting-state fMRI study
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DOI：
10.1212/wnl.0000000000007577
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发表时间：
2019-05-28
期刊：
影响因子：
9.9
通讯作者：
Pierelli, Francesco
中科院分区：
文献类型：
--
作者：
Coppola, Gianluca;Di Renzo, Antonio;Pierelli, Francesco
我们研究静息状态（RS）-fMRI使用独立成分分析（伊卡），以确定慢性偏头痛（CM）患者的网络之间的功能连接（FC）及其与临床features.MethodsTwenty CM患者没有预防性治疗或急性药物过度使用进行了3 T MRI扫描，并与一组20名健康对照（HC）进行了比较。我们使用MRI收集RS数据在3个选定的网络，确定使用组伊卡：默认模式网络（DMN），执行控制网络（ECN），和背侧注意系统（DAS）。此外，在患者中，DAS显示DMN的FC明显更强，ECN的FC较弱。头痛的严重程度越高，DAS连接的强度增加，ECN connections.ConclusionThese结果的强度降低提供了证据，大规模重组的功能性皮层网络在慢性偏头痛。他们认为头痛的严重程度与额叶执行和背侧注意网络中相反的连接模式有关。
ObjectiveWe investigated resting-state (RS)-fMRI using independent component analysis (ICA) to determine the functional connectivity (FC) between networks in chronic migraine (CM) patients and their correlation with clinical features.MethodsTwenty CM patients without preventive therapy or acute medication overuse underwent 3T MRI scans and were compared to a group of 20 healthy controls (HC). We used MRI to collect RS data in 3 selected networks, identified using group ICA: the default mode network (DMN), the executive control network (ECN), and the dorsal attention system (DAS).ResultsCompared to HC, CM patients had significantly reduced functional connectivity between the DMN and the ECN. Moreover, in patients, the DAS showed significantly stronger FC with the DMN and weaker FC with the ECN. The higher the severity of headache, the increased the strength of DAS connectivity, and the lower the strength of ECN connectivity.ConclusionThese results provide evidence for large-scale reorganization of functional cortical networks in chronic migraine. They suggest that the severity of headache is associated with opposite connectivity patterns in frontal executive and dorsal attentional networks.