Inflammation in abdominal aortic aneurysms: cellular infiltrate and cytokine profiles
Inflammation in abdominal aortic aneurysms: cellular infiltrate and cytokine profiles
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DOI：
10.1258/vasc.2011.201207
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发表时间：
2012-10-01
期刊：
影响因子：
1.1
通讯作者：
Eagleton, Matthew J.
中科院分区：
文献类型：
--
作者：
Eagleton, Matthew J.
腹主动脉瘤 (AAA) 发病机制是主动脉血管壁结构蛋白稳态改变的结果。这导致主动脉减弱并随后扩张，导致动脉瘤形成。这一过程涉及多种机制，包括遗传异常、生物力学壁应激、细胞凋亡和主动脉壁的蛋白水解降解。这种病理学的一个关键标志是炎症，它协调各种病理过程的相互作用。炎症过程的特点是多种细胞的浸润，导致多种细胞因子的上调。细胞类型和由此产生的细胞因子环境的平衡决定了主动脉壁的最终命运——愈合、动脉粥样硬化或动脉瘤形成。这篇综述重点介绍了一些与主动脉瘤形成有关的已知细胞和细胞因子炎症事件。
Abdominal aortic aneurysm (AAA) pathogenesis occurs as a result of the altered homeostasis of the aortic vessel wall structural proteins. This results in weakening, and subsequent expansion, of the aorta leading to aneurysm formation. Multiple mechanisms are involved in this process, including genetic abnormalities, biomechanical wall stress, apoptosis, and proteolytic degradation of the aortic wall. One key hallmark of this pathology, which orchestrates the interaction of the various pathologic processes, is inflammation. The inflammatory process is characterized by the infiltration of a variety of cells, which leads to the upregulation of multiple cytokines. The balance of the cellular type and resultant cytokine milieu determines the ultimate fate of the aortic wall - healing, atherosclerosis or aneurysm formation. This review highlights some of the known cellular and cytokine inflammatory events that are involved in aortic aneurysm formation.