Altered negative unconscious processing in major depressive disorder: an exploratory neuropsychological study.
Altered negative unconscious processing in major depressive disorder: an exploratory neuropsychological study.
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重度抑郁症中消极无意识处理的改变：一项探索性神经心理学研究
DOI：
10.1371/journal.pone.0021881
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Northoff G
中科院分区：
文献类型：
--
作者：
Yang Z;Zhao J;Jiang Y;Li C;Wang J;Weng X;Northoff G
目的重度抑郁障碍（MDD）以情绪加工异常为特征。然而，尚不清楚的是，重度抑郁症是否也表现出无意识处理积极或消极情绪的缺陷。我们在健康和重度抑郁症受试者中进行了一项心理研究，以调查重度抑郁症患者的无意识情绪加工及其价特异性改变。方法结合已建立的无意识视觉加工范式——连续闪光抑制和积极情绪效价和消极情绪效价，检测无形情绪面部表情引起的注意偏好。结果健康受试者在无意识状态下对负性情绪表现出注意偏倚，而重度抑郁症患者不存在这种效价偏倚。相比之下，健康受试者和重度抑郁症患者在有意识状态下，这种注意偏倚都减少了。结论我们的研究结果首次证明了MDD患者在无意识情绪加工中存在价特异性缺陷；这可能对随后的神经生物学研究以及临床诊断和治疗具有重大意义。
Objective Major depressive disorder (MDD) has been characterized by abnormalities in emotional processing. However, what remains unclear is whether MDD also shows deficits in the unconscious processing of either positive or negative emotions. We conducted a psychological study in healthy and MDD subjects to investigate unconscious emotion processing and its valence-specific alterations in MDD patients. Methods We combined a well established paradigm for unconscious visual processing, the continuous flash suppression, with positive and negative emotional valences to detect the attentional preference evoked by the invisible emotional facial expressions. Results Healthy subjects showed an attentional bias for negative emotions in the unconscious condition while this valence bias remained absent in MDD patients. In contrast, this attentional bias diminished in the conscious condition for both healthy subjects and MDD. Conclusion Our findings demonstrate for the first time valence-specific deficits specifically in the unconscious processing of emotions in MDD; this may have major implications for subsequent neurobiological investigations as well as for clinical diagnosis and therapy.
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