Giant migrating contractions during defecation in the dog colon.
Giant migrating contractions during defecation in the dog colon.
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狗结肠排便时出现巨大的迁移性收缩。
DOI：
10.1016/0016-5085(87)90966-8
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发表时间：
1987
期刊：
影响因子：
29.4
通讯作者：
Sarna,SK
中科院分区：
文献类型：
--
作者：
Karaus,M;Sarna,SK
在5只清醒的狗中研究了排便的结肠运动相关性：在每只狗的结肠上植入一组6个应变计传感器。植入的插管可进入末端回肠。在230小时的总控制记录期间，我们观察到12次大幅度收缩，这些收缩在近端结肠自发发生并向尾部迁移。我们称之为巨大的迁移收缩。这些收缩的平均幅度是2.8倍大于结肠运动复合体的平均峰值幅度的阶段性收缩。施加以下刺激以诱导排便：2 mg/kg乙啶（i. v.），30 μg/kg新斯的明（i，v.），1-4 mg/kg蓖麻油（p.o.），200 ml 25%葡萄糖（回肠），并通过球囊（120 ml）扩张直肠。在使用乙啶、新斯的明、葡萄糖和蓖麻油的实验中，85%的实验在排便前出现巨大的移行性收缩。巨大的迁移性收缩迁移到整个结肠或其部分长度。移位速度为0.2 ~ 3.2cm/s（平均值±标准差，0.82 ± 0.1cm/s）。在11%的实验中，巨大的收缩几乎同时发生在排便时的不同记录部位。在4%的实验中，巨大的收缩只发生在一个部位。球囊排出很少伴有结肠巨大收缩，然后仅发生在远端部位，未发生移位。我们的结论是，结肠具有自发但罕见的大幅度尾部移行收缩。这些收缩可能是运动等效的质量运动。排便前通常伴有结肠巨大移行性收缩。巨大的移行性收缩可能提供排便的主要力量，并在排便过程中部分负责结肠的排空。然而，疏散的内容，如气球似乎是可能的，没有巨大的迁移收缩。
The colonic motor correlates of defecation were studied in 5 conscious dogs: A set of six strain-gauge transducers were implanted on the colon of each dog. An implanted cannula gave access to the terminal ileum. During a total control recording period of 230 h we observed 12 large-amplitude contractions that occurred spontaneously in the proximal colon and migrated caudal. We called them giant migrating contractions. The mean amplitude of these contractions was 2.8 times larger than the mean peak amplitude of phasic contractions during colonic motor complexes. The following stimuli were applied to induce defecation: 2 mglkg guanethidine (i.v.), 30 μg/kg neostigmine (i,v.), 1–4 mglkg castor oil (p.o.), 200 ml of 25% glucose (into ileum), and rectal distention by a balloon (120 ml). In 85% of experiments with guanethidine, neostigmine, glucose, and castor oil, giant migrating contractions occurred before defecation. The giant migrating contractions migrated over the entire colon or a part of its length. The migration velocity varied from 0.2 to 3.2 cm/s (mean ± SE, 0.82 ± 0.1 cmls). In 11% of the experiments, giant contractions occurred almost simultaneously at different recording sites at the time of defecation. In 4% of the experiments giant contractions occurred only at a single site. Balloon expulsion was only rarely accompanied by giant contractions in the colon, and then occurred only at a distal site and did not migrate. We conclude that the colon has spontaneous but infrequent largeamplitude caudal-migrating contractions. These contractions may be the motor equivalent of mass movements. Defecation is usually preceded by colonic giant migrating contractions. The giant migrating contractions may provide a major force for defecation and be partially responsible for the evacuation of the colon during defecation. However, evacuation of contents such as a balloon seems to be possible without giant migrating contractions.