An analysis of skin prick test reactions in 656 asthmatic patients.
An analysis of skin prick test reactions in 656 asthmatic patients.
复制标题
656 例哮喘患者皮肤点刺试验反应分析。
作者：
D. Hendrick;R. Davies;M. D'souza;J. Pepys
在656名哮喘患者中，有544名（84%）患者对22种常见过敏原中的至少一种进行了阳性皮肤点刺试验。这些皮肤试验阳性患者与102名（16%）皮肤试验阴性患者的比较显示出许多显著差异。大多数皮肤试验阳性患者（52%）在哮喘发作时不到10岁，而在皮肤试验阴性患者中，56%在发作时年龄超过30岁。70%的人报告鼻炎，而皮肤试验阴性的患者为48%，29%的人报告婴儿湿疹，而皮肤试验阳性的患者为9%。而皮质类固醇药物在皮肤试验阴性的患者中使用更普遍（45%对35%）。与其他因素的研究，即荨麻疹或血管性水肿的历史，家族史的“过敏性”疾病，并认识到敏感性的食物，阿司匹林或青霉素没有显着差异。皮试阳性患者的点刺试验反应最常见的是房屋灰尘或螨螨、粉尘螨（82%），其次是花粉（66%）、动物皮屑（38%）、食物（16%）、烟曲霉（16%）和其他霉菌（21%）。有一个非常显着的关联，阳性史与阳性点刺试验的所有过敏原研究。
Of 656 asthmatic patients referred specifically for allergy assessments, 544 (84 percent) gave positive immediate skin prick tests to at least one of 22 common allergens used routinely. Comparison of these skin test positive patients with the 102 (16 percent) who were skin test negative showed a number of significant differences. The majority of the skin test positive patients (52 percent) were less than 10 years old at the time of onset of the asthma, whereas, of the skin test negative patients, 56 percent were aged over 30 years at the time of onset. Seventy per cent report rhinitis compared with 48 per cent of the skin test negative patients, and 29 per cent reported infantile eczema compared with 9 per cent. Symptoms attributed to house dust, pollens, and animals were noted two to three times more frequently by the skin test positive patients, while corticosteroid drugs had been used more commonly by the skin test negative patients (45 percent compared with 35 percent). No significant differences were observed with the other factors studied, namely, history of urticaria or angio-oedema, family history of "allergic" disease, and awareness of sensitivity to foods, aspirin or penicillin. Prick test reactions in the skin test positive patients were most commonly seen to house dust or the acarine mite, Dermatophagoides farinae (82 percent), followed by pollens (66 percent), animal danders (38 percent), foods (16 percent), Aspergillus fumigatus (16 percent), and other moulds (21 percent). There was a highly significant association of positive history with positive prick test for all allergens studied.