Inhibition of E-coli growth by fullerene derivatives and inhibition mechanism
Inhibition of E-coli growth by fullerene derivatives and inhibition mechanism
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DOI：
10.1016/s0960-894x(99)00515-6
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发表时间：
1999-10-18
影响因子：
2.7
通讯作者：
Mochizuki, M
中科院分区：
文献类型：
--
作者：
Mashino, T;Okuda, K;Mochizuki, M
阳离子富勒烯氨衍生物(C-60-双(N，N-二甲基吡咯烷碘)和C-60-双(N-甲基哌嗪碘))对大肠杆菌生长有抑制作用，而阴离子衍生物(C-60-二丙二酸)则无抑制作用。两种阳离子衍生物均能抑制大肠杆菌的氧气消耗。认为抑制能量代谢是富勒烯类化合物抑制生长的机制之一。(C)1999爱思唯尔科学有限公司。保留所有权利。
Cationic ammonium fullerene derivatives (C-60-bis(N, N-dimethylpyrrolidinium iodide) and C-60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C-60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives. (C) 1999 Elsevier Science Ltd. All rights reserved.