Effect of postmenopausal estrogen replacement on circulating androgens
Effect of postmenopausal estrogen replacement on circulating androgens
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DOI：
10.1016/s0029-7844(97)00538-3
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发表时间：
1997-12-01
影响因子：
7.2
通讯作者：
Snabes, MC
中科院分区：
文献类型：
--
作者：
Casson, PR;ElkindHirsch, KE;Snabes, MC
目的：探讨雌激素替代疗法(ERT)对绝经后妇女血清雄激素水平的影响。方法：采用随机、盲法、安慰剂对照交叉试验方法，测定28例绝经后妇女(27例自然绝经后)上午8：00空腹血清中脱氢表雄酮(DHEA)、脱氢表雄酮硫酸盐(DHEA-硫酸盐)、睾酮(T)、雌二醇(E_2)、促黄体生成素(FSH)、性激素结合球蛋白(FSH)及性激素结合球蛋白。结果：雌激素替代治疗使血清雌二醇水平从8.7+/-1.0上升到117+/-18.7 pg/m L(P
Objective: To determine the effect of estrogen replacement therapy (ERT) on serum androgen levels in postmenopausal women.Methods: We measured serum dehydroepiandrosterone (DHEA), DHEA-sulfate, testosterone, estradiol (E2), LH, FSH, and sex hormone binding globulin in 8:00 AM fasting serum samples from a previous randomized, blinded, placebo-controlled crossover study in which 28 postmenopausal women (27 naturally menopausal) were given 2 mg/day of oral micronized estradiol. The treatment arms were 12 weeks with a 6-week washout.Results: Estrogen replacement therapy raised mean (+/- standard error of the mean [SEM]) serum E2 from 8.7 +/- 1.0 to 117 +/- 18.7 pg/mL (P