The modification of natural products for medical use.
The modification of natural products for medical use.
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DOI：
10.1016/j.apsb.2016.06.003
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Guo Z
中科院分区：
文献类型：
--
作者：
Guo Z
药物创新的特点是艰苦的分子水平合成和修饰作为研发的基本组成部分。同样，天然产物根据其结构和生物特性进行化学定制和修饰。在某种程度上，天然产物的修饰与基于从头结构的药物发现有很大不同。本综述描述了天然产物修饰为药物的一般策略和原则，并以几种源自天然产物的成功药物为例进行了说明。本综述描述了天然产物修饰为药物的一般策略和原则，并以几种源自天然产物的成功药物为例进行了说明。
Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural products is quite different from de novo structure-based drug discovery. This review describes the general strategies and principles for the modification of natural products to drugs, as illustrated by several successful medicines that originated from natural products. This review describes the general strategies and principles for the modification of natural products to drugs, as illustrated by several successful medicines that originated from natural products.