Inflammation, atrophy, and prostate carcinogenesis
Inflammation, atrophy, and prostate carcinogenesis
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DOI：
10.1016/j.urolonc.2007.05.007
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发表时间：
2007-09-01
影响因子：
2.7
通讯作者：
Nelson, William G.
中科院分区：
文献类型：
--
作者：
De Marzo, Angelo M.;Nakai, Yasutomo;Nelson, William G.
导致前列腺癌的病因仍不清楚。有新的证据表明，被认为代表再生上皮的“危险因素”损害可能先于前列腺上皮内瘤变和早期癌的发展。最近的证据表明，这些损害，统称为增殖性炎性萎缩，可能发生在炎症和饮食毒素的背景下，如“焦肉”致癌物质。需要做更多的流行病学、分子病理学和动物模型研究，以确定炎症和萎缩是否“推动”前列腺癌的发生。(C)2007 Elsevier Inc.保留所有权利。
The etiological agents that cause prostate cancer remain unknown. There is emerging evidence that "risk factor" lesions that are proposed to represent regenerative epithelium in response to environmental insults may precede the development of prostatic intraepithelial neoplasia and early carcinoma. Recent evidence suggests that these lesions, referred to collectively as proliferative inflammatory atrophy, may arise in the setting of inflammation and dietary toxins, such as "charred meat" carcinogens. Additional epidemiological, molecular pathological, and animal model work needs to be done to determine whether inflammation and atrophy are "driving" prostate carcinogenesis. (C) 2007 Elsevier Inc. All rights reserved.