Review of G and P typing results from a global collection of rotavirus strains: Implications for vaccine development
Review of G and P typing results from a global collection of rotavirus strains: Implications for vaccine development
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DOI：
10.1093/infdis/174.supplement_1.s30
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发表时间：
1996-09-01
影响因子：
6.4
通讯作者：
Glass, RI
中科院分区：
文献类型：
--
作者：
Gentsch, JR;Woods, PA;Glass, RI
候选轮状病毒疫苗已经用重新组合的毒株制备，专门用于预防4种主要的轮状病毒G血清型(G1-4)。许多使用P(VP4)基因分型方法的研究表明，在世界范围内，4种常见G血清型的轮状病毒毒株都与1个P基因型相关：G1、G3和G4与P[8]相关，G2与P[4]相关。相比之下，印度轮状病毒样本的G和P基因分型显示，儿童腹泻病毒株中有很高比例属于P[6]型，最常见的株具有不寻常的G血清型，G9。同样，在巴西调查的所有地区，在患有胃肠炎的儿童中发现了明显的P[8]、G5基因重排。这些研究表明，虽然轮状病毒毒株在许多环境中的多样性有限，但在某些环境中可能会出现常见和不常见的血清型或动物毒株之间的重新分类，从而导致不寻常的多样性。
Candidate rotavirus vaccines have been prepared with reassortant strains specifically to protect against the 4 major rotavirus G serotypes (G1-4). Many studies using P (VP4) genotyping methods have indicated that, worldwide, rotavirus strains of the 4 common G serotypes are each associated with 1 P genotype: G1, G3, and G4 are associated with P[8], and G2 is associated with P[4]. In contrast, G and P genotyping of rotavirus in specimens from India revealed that a high percentage of the childhood diarrhea strains belong to genotype P[6], and the most common strain had an unusual G serotype, G9. Similarly, in all regions surveyed in Brazil, apparent reassortants of genotype P[8], G5 were found in children with gastroenteritis. These studies indicate that while rotavirus strains have limited diversity in many settings, reassortment between common and uncommon serotypes or animal strains can arise in some settings and, thus, lead to unusual diversity.