The role of Neuropilin-1 in COVID-19.
The role of Neuropilin-1 in COVID-19.
复制标题
神经匹林-1在新冠肺炎中的作用。
DOI：
10.1371/journal.ppat.1009153
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发表时间：
2021-01
期刊：
影响因子：
6.7
通讯作者：
Raja A
中科院分区：
文献类型：
--
作者：
Mayi BS;Leibowitz JA;Woods AT;Ammon KA;Liu AE;Raja A
神经纤毛蛋白-1（NRP-1）是一个信号蛋白家族成员，在体外被证明是SARS冠状病毒2（SARS-CoV-2）的进入因子并增强其感染性。这种细胞表面受体及其弥散性表达在血管生成、肿瘤进展、病毒进入、轴突导向和免疫功能中是重要的。NRP-1与SARS-CoV-2感染的几个方面有关，包括可能通过嗅球传播并进入中枢神经系统，以及2019年严重冠状病毒病（COVID-19）肺部NRP-1 RNA表达增加。糖尿病肾细胞中NRP-1蛋白的上调暗示了其在严重COVID-19风险人群中的重要性。鉴于过度的免疫反应在COVID-19导致的疾病严重程度和死亡中的作用，NRP-1参与免疫功能是令人信服的。NRP-1被认为是T细胞记忆的免疫检查点。目前尚不清楚NRP-1在COVID-19中的参与和上调是否会转化为疾病结果和长期后果，包括可能的免疫功能障碍。NRP-1及其作为SARS-CoV-2感染治疗靶点的可能性值得进一步研究。我们预计，NRP-1的广泛表达、在呼吸道和嗅觉上皮中的丰度以及其功能性是COVID-19的多种全身效应以及我们在疾病管理和潜在长期后遗症方面面临的挑战的因素。
Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro. This cell surface receptor with its disseminated expression is important in angiogenesis, tumor progression, viral entry, axonal guidance, and immune function. NRP-1 is implicated in several aspects of a SARS-CoV-2 infection including possible spread through the olfactory bulb and into the central nervous system and increased NRP-1 RNA expression in lungs of severe Coronavirus Disease 2019 (COVID-19). Up-regulation of NRP-1 protein in diabetic kidney cells hint at its importance in a population at risk of severe COVID-19. Involvement of NRP-1 in immune function is compelling, given the role of an exaggerated immune response in disease severity and deaths due to COVID-19. NRP-1 has been suggested to be an immune checkpoint of T cell memory. It is unknown whether involvement and up-regulation of NRP-1 in COVID-19 may translate into disease outcome and long-term consequences, including possible immune dysfunction. It is prudent to further research NRP-1 and its possibility of serving as a therapeutic target in SARS-CoV-2 infections. We anticipate that widespread expression, abundance in the respiratory and olfactory epithelium, and the functionalities of NRP-1 factor into the multiple systemic effects of COVID-19 and challenges we face in management of disease and potential long-term sequelae.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
影响因子：
4.5
作者：
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通讯作者：
Dodé C
影响因子：
13.6
作者：
通讯作者：
--
影响因子：
3.7
作者：
Bechet, Denise;Tirand, Loraine;Barberi-Heyob, Muriel
通讯作者：
Barberi-Heyob, Muriel
DOI：
10.1242/dev.063362
发表时间：
2011-09
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Cariboni A;Davidson K;Dozio E;Memi F;Schwarz Q;Stossi F;Parnavelas JG;Ruhrberg C
通讯作者：
Ruhrberg C