Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis
Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis
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DOI：
10.1139/h11-082
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发表时间：
2011-12-01
影响因子：
3.4
通讯作者：
Newhouse, Ian J.
中科院分区：
文献类型：
--
作者：
McMillan, Elliott M.;Newhouse, Ian J.
使用运动干预来管理癌症相关性疲劳（CRF）是一个快速发展的研究领域。然而，结果是不一致的，很难解释整个文献，使得它很难得出准确的结论，运动干预的真正有效性的CRF管理。本研究的目的是应用荟萃分析来定量评估运动干预策略对CRF的影响，并阐明适当的运动处方指南。对电子数据库、相关期刊和文章进行了系统检索。如果受试者年龄超过18岁，如果他们被诊断为癌症或接受过癌症治疗，如果运动被用于治疗CRF作为主要或次要终点，如果干预的效果被定量评估并提供了足够的统计数据进行分析，则研究合格。共有16项研究，代表1426名参与者（运动，759;对照，667）被纳入使用固定效应模型的荟萃分析。采用标准化均数差异效应量（SMD）检验运动对实验组和对照组CRF的影响。结果表明，使用运动干预减少CRF的效果较小但显著（SMD 0.26，p < 0.001）。此外，有氧运动计划导致CRF显著降低（SMD 0.21，p < 0.001），总体而言，与对照组相比，运动能够显著改善有氧和肌肉骨骼健康（p < 0.01）。运动对CRF病理生理学相关潜在机制的影响仍需进一步研究。
The use of exercise interventions to manage cancer-related fatigue (CRF) is a rapidly developing field of study. However, results are inconsistent and difficult to interpret across the literature, making it difficult to draw accurate conclusions regarding the true effectiveness of exercise interventions for CRF management. The aims of this study were to apply a meta-analysis to quantitatively assess the effects of exercise intervention strategies on CRF, and to elucidate appropriate exercise prescription guidelines. A systematic search of electronic databases and relevant journals and articles was conducted. Studies were eligible if subjects were over the age of 18 years, if they had been given a diagnosis of or had been treated for cancer, if exercise was used to treat CRF as a primary or secondary endpoint, and if the effects of the intervention were evaluated quantitatively and presented adequate statistical data for analysis. A total of 16 studies, representing 1426 participants (exercise, 759; control, 667) were included in a meta-analysis using a fixed-effects model. The standardized mean difference effect size (SMD) was used to test the effect of exercise on CRF between experimental and control groups. The results indicate a small but significant effect size in favour of the use of exercise interventions for reducing CRF (SMD 0.26, p < 0.001). Furthermore, aerobic exercise programs caused a significant reduction in CRF (SMD 0.21, p < 0.001) and overall, exercise was able to significantly improve aerobic and musculoskeletal fitness compared with control groups (p < 0.01). Further investigation is still required to determine the effects of exercise on potential underlying mechanisms related to the pathophysiology of CRF.