Heritability of ambulatory and office blood pressure phenotypes in Swedish families
Heritability of ambulatory and office blood pressure phenotypes in Swedish families
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DOI：
10.1097/00004872-200409000-00015
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发表时间：
2004-09-01
影响因子：
4.9
通讯作者：
Melander, O
中科院分区：
文献类型：
--
作者：
Fava, C;Burri, P;Melander, O
目的探讨24小时动态血压和办公室血压在瑞典家庭中的遗传度。方法对118个家庭中260名未经降压治疗的兄弟姐妹进行动态血压和办公室血压测量。结果夜间收缩压(37%)、舒张压(32%)和平均动态血压(32%)的遗传力值具有统计学意义(P均0.05)。白天，动态收缩压有显著的遗传性(33%，P<；0.05)。24小时动态血压中的收缩压(30%)和舒张压(29%)也有显著的遗传度(P<；0.05)。脉压动态血压在24小时以上(63%，P<；0.01)、白天(53%，P<；0.01)和夜间(34%，P<；0.05)有显著的遗传性。结论动态血压，特别是夜间动态血压似乎比办公室血压更能反映血压的可遗传部分，提示动态血压可能是对个体真实血压的更准确的估计。使用动态血压作为表型的遗传学研究可能比使用办公室血压的基因研究更有效。脉压动态血压的高遗传率表明，没有服用降压药的受试者动脉僵硬的变化受到遗传因素的强烈影响。(C)2004年，里平科特·威廉姆斯·威尔金斯。
Objective The aim of this study was to estimate the heritability of 24-h ambulatory blood pressure and office blood pressure phenotypes in Swedish families.Methods We measured ambulatory and office blood pressure in 260 siblings without anti hypertensive treatment from 118 families. Blood pressure heritability was estimated using standard quantitative genetic variance component analysis implemented in the 'SOLAR' software package after adjustment for significant covariates.Results Heritability values were significant for night-time systolic (37%), diastolic (32%) and mean (32%) ambulatory blood pressure (P < 0.05 for all). During daytime, systolic ambulatory blood pressure was significantly heritable (33%, P < 0.05). Twenty-four-hour systolic (30%) and diastolic (29%) ambulatory blood pressure also had significant values of heritability (P < 0.05). Pulse pressure ambulatory blood pressure was significantly heritable over 24 h (63%, P < 0.01), during daytime (53%, P < 0.01) and at night (34%, P < 0.05). None of the office blood pressure phenotypes had a significant heritability.Conclusions We conclude that ambulatory blood pressure, in particular at night, seems better than office blood pressure to capture the heritable part of blood pressure, suggesting that ambulatory blood pressure may be a more exact estimate of an individual's true blood pressure. Genetic studies using ambulatory blood pressure as the phenotype are likely to be more powerful than those using office blood pressure. The high heritability of pulse pressure ambulatory blood pressure indicates that variation in arterial stiffness in subjects free from antihypertensive medication is strongly affected by genetic factors. (C) 2004 Lippincott Williams Wilkins.